DOSING: Conscious sedation – (IM) 0.07-0.08 mg/kg 30-60 min before procedure
(IV) 1-1.5 mg, may repeat in 2 min prn
Intubated pts – 0.05 – 0.2 mg/kg/hr by continuous infusion
THERAPEUTIC EFFECTS: CNS depressant with muscle relaxant, sedative-hypnotic, anticonvulsant, and amnestic properties
USES: sedation before general anesthesia, induction of general anesthesia; to impair memory of perioperative events
(anterograde amnesia); conscious sedation prior to short diagnostic and endoscopic procedures; hypnotic supplement to nitrous
oxide and oxygen (balances anesthesia) for short surgical procedures.
IMPLICATIONS: inspect insertion site for redness, swelling and pain, signs of extravasation during IV infusion
• Monitor for hypotension, especially it pt is also receiving narcotic agonist
• Monitor vitals during entire recovery period. In obese pts, half life is prolonged during IV infusion, therefore duration
of effect is prolonged
• Overdose symptoms may include somnolence, confusion, sedation, diminished reflexes, coma, and untoward effect on
vital signs
TEACHING: do not drive or engage in hazardous activities until response to drug is known.
• You may feel drowsy, weak or tired for 1-2 d after drug has been given
• Be prepared for amnesia to prevent an upsetting post-op period
• Review written instructions to assure future understanding and compliance. Pt teaching during amnestic period may not
be remembered. Even if dose is small, and depth of amnesia is unclear, relearn information.