BIO 300 #2 Metabolism and Cell Dysfunction

Metabolism
Definitions:
Metabolism____________________________________________________
Catabolism_____________________________________________________
Anabolism_____________________________________________________

What is the role of ATP in metabolism? Why is it important for normal cell function?

What are the primary means of ATP production and where do these processes occur?

Altered Cell and Tissue Function

3 types of cells by regenerative abilities
1. Permanent cells-

2. Stable cells-

3. Labile Cells

As a result of cell injury what are the potential adaptations a cell can undergo?

1.Altered Growth
A. Atrophy

B. Hypertrophy

C. Hyperplasia

2. Altered Differentiation
A. Metaplasia

B. Dysplasia

C. Neoplasia

What are the characteristics of a benign and malignant tumors?

Benign Malignant

Which of these types of tumors is considered cancer?

Cell Injury
Which sites within the cell are important in cell injury? Why?
1.

2.

3.

4.

John is a 45 year-old building contractor who experienced mild chest discomfort after moving
some bags of concrete. His doctor determined that he was experiencing myocardial ischemia.
What is ischemia and what are the expected effects on the myocardium?

Manifestations of cell injury

1.

2.

3.

What are the hallmarks of reversible and irreversible cell injury?

Reversible Irreversible

Necrosis and Apoptosis

Definitions:
Necrosis_____________________________________________
Apoptosis____________________________________________
Karyolysis____________________________________________
Pyknosis_____________________________________________
Karyorrhexis__________________________________________

What are the different forms of necrosis, what are the common signs and where are the common
sites of each?
1.

2.

3.
4.

5.

What are a few examples of normal physiological apoptosis:

Compare and contrast apoptosis and necrosis: