Anda di halaman 1dari 18

Reverse

Vaccinology

Wage Indrya Nugraha

h=p://www.wired.com/science/discoveries/news/2008/05/dayintech_0514#

Edward Jenner 1796

Louis Pasteur 1886

h"p://www.icollector.com/Louis-Pasteur_i9688850

Reverse Vaccinology
1. Analisis komputer (In Silico) 2.IdenRkasi anRgen 3. Animal test 4. Molecular epidemology 5. Uji klinis 6. Ijin dari regulator 7. Rekomendasi 8. Implementasi

Rappuoli R. (2010). Reverse vaccinology. Immunity Review 33 : 530-541.

Vaccinomic

Rappuoli, R (2000). Reverse Vaccinology. Genomics. 445-450.

Reverse Vaccinology
Biology Molekuler, Immunology, Genomic (-Omic), Komputasi & BioinformaRc.

Reverse Vaccinology
Epitope ; an=genic determinant Bagian/sisi anRgen Yang dikenali oleh reseptor AnRgen/AnRbodi. AnRgen : Molekul yang dikenali oleh sistem kekebalan tubuh

Reverse Vaccinology

Reverse Vaccinology
Epitope Linier & Epitope Non Linier

Reverse Vaccinology

Reverse Vaccinology

Reverse Vaccinology
BioinformaRc Public Domain, Desktop Applica=on (Free access-proprietary) : IEDB, ELLIPRO, GENEIOUS, CLC-BIO, EPIVAX, VAXIGN

Vaccinomic

Reverse Vaccinology
Grup B Meningococcus, Malaria, Tuberculosis, Syphilis, HepaRRs-B, HepaRRs-C

Daiar Pustaka
H=p://www.epivax.com . h=p://www.immuneepitope.org/ . De Groot, Anne S., Cohen, Tobias., Ardito, Ma=hew.,(2010) Use of BioinformaRka to Predict MHC Ligands and T-Cell Epitopes: ApplicaRon to Epitope-Driven Vaccine Design. Methods in Microbiology.37:35-66. Rappuoli, R., Se=e, Alessandro., (2010). Reverse Vaccinology:Developing Vaccines in The Era of Genomics. Immunity. 33, 530-541. Vivona, Sandro., Gardy, J.L., (2008). Computer-aided biotechnology: from immun-informaRcs to reverse vaccinology.Trends in Biotechnology. 26, 190-200. Von Reyn, Fordham., Vuola, Jenni., (2002) New Vaccine for the PrevenRon of Tuberculosis. Vaccine 35:465-474. WHO, (2011) WHO Report ; Global Tuberculosis Control 2011. France. Xiong, Jin., (2006) Essen=al Bioinforma=cs. Cambridge University Press. New York.

TERIMAKASIH

PT. Bio Farma Vaccine & Sera Manufacturer ; Dedicated to Public Health since 1890

Anda mungkin juga menyukai