Predisposing Factors: Sex; Race; Age; Genetics Hepatitis B Virus (HBV) Precipitating Factors: Environment; Lifestyle; History of blood transfusion
Cell-mediated immune response Phase I: INCUBATION PERIOD Direct lysis of infected cells
S/Sx: Arthralgia; Malaise; Fatigue; Low grade fever; Urticaria; Pruritus S/Sx: Asymptomatic Labs: (+) serologic and enzyme markers
Leakage of HBV into the bloodstream towards the system Triggers inflammatory chemical mediators (Cytokines; interleukins; histamines)
Phase
II:
Pre-Icteric
S/Sx: Hepatomegaly; tender liver Labs WBC
Accumulation of WBC and macrophages Liver inflammation/necrosis Impaired bile synthesis & metabolism Decreased Fat absorption Phase III: Icteric phase
A. B . 22
Hyperbilirubinemia
S/Sx: Jaundice; Icteric sclera; dark colored urine
Fatty Stool
S/Sx: Steatorrhea
Bleeding
Anemia
RBC
Phase IV: Convalescence Complications: - Liver Cirrhosis - Hepatocellular cancer - Fulminant hepatic failure - Coagulopathy - Hepatic encepalophathy - Cerebral edema
GOOD PROGNOSIS
DEATH
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