LOCAL ANESTHESIA
FOR MINOR OPERATION
Local anesthesia
Classification
Ester group:
chioroprocaine, procaine, teracaine, cocaine
pseudocholinesterase enzyme plasma
alcohol and paraamino benzoic acid
Amide group:
Lidocaine, mepivacaine, etidocaine, prilocaine,
bupivacaine, ropivacaine
microsomal enzyme
Local anesthesia
Local anesthesia
Potency
Increase in Cm (minimum concentration)
Acid
Ca, K
Size of nerve fiber, Na channel, myelin sheath,
between Nodes of Ranvier
Except B fiber
Local anesthesia
pKa:
mepivacaine > lidocaine > etidocaine > ropivacaine >
bupivacaine > tetracaine > chloroprocaine
Local anesthesia
Duration:
1 acid glycoprotein 1 3 hr
:
Conc., circulation and vessel
Distribution:
Tissue perfusion
Tissue/blood partition coefficient
Tissue mass
Local anesthesia
Maximum dose
(./.)
Amide
Bupivacaine (Marcaine)
Lidocaine (xylocaine)
Etidocaine (Duranest)
Mepivacaine (Carbocaine)
Prilocaine (Citanest)
Ropivacaine
Dibucaine (Nupercaine)
Ester
3
4.5 7
4
4.5 7
4.5 7
3
1
Local anesthesia
Maximum dose
(./.)
Amide
Ester
Chloroprocaine (Nesacaine)
Tetracaine (Pontacaine)
Cocaine
Procaine
12
3
3
12
Local anesthesia
Systemic toxicity
Intravascular injection
Absorption ~20 min after use
Concentration
Rate of infusion
Potency
Tissue perfusion
Combinated with vasoconstrictive agent
Local anesthesia
Systemic toxicity (CNS)
excitation
depression
-
-
-
-
-
Local anesthesia
Systemic toxicity (CNS)
excitation
(Blockage of Inhibitory
pathway)
depression
-
-
-
-
- GTC
Local anesthesia
Systemic toxicity (CNS)
excitation
depression
-
-
-
-
-
Local anesthesia
Systemic toxicity (CVS)
-
-
Local anesthesia
Systemic toxicity (CVS)
-
-
-
Local anesthesia
Systemic toxicity (CVS)
-
-
-
-
Local anesthesia
Systemic toxicity (RS)
hypoxic drive
medullary respiratory center
Local anesthesia
Others systemic toxicity
aminoester
Methemoglobinemia prilocaine, benzocaine
Tissue toxicity
Local anesthesia
:
:
Diazepam 0.1 mg/kg
Resuscitation
Antihistamine steroid
Oxygen supplement
Local anesthesia
Lidocaine (Xylocaine)
Amide group
Onset: 5 10 mins
Duration: ~100 mins
Maximum dose:
4.5 mg/kg in w/o vasoconstrictive agent
7 mg/kg in with vasoconstrictive agent
Local anesthesia
Topical anesthesia:
Cocaine, Amethocaine, Lignocaine, Prilocaine
Onset 5 10 mins
Duration 30 60 mins
Infiltration anesthesia
Unmyelinated nerve ending blockage
Rapid onset of action
Method
SEBACEOUS CYST
AND LIPOMA
THE NAIL
The Nail
Nail extraction
Paronychia
Subungual hematoma
Wart
table
Wart
Lentigo
Nevus