Penentuan Profil Laju Disolusi Tablet Lepas Lambat Asetosal

Tablet I
5 0,0286 A
0,0286

= 0,005x 0,036

= 0,0286 + 0,036
0,005
= 12,92 g/mL

Dalam 1000 mL larutan

= 12,92 g/mL x 900 mL
= 11628 g
= 11,628 mg

% disolusi = 11,628 x 100%

250
= 4,65 %
10 0,0415 A
0,0415

= 0,005x 0,036

= 0,0415 + 0,036
0,005
= 15,5 g/mL

Dalam 1000 mL larutan

= 15,5 g/mL x 900 mL
= 13950 g
= 13,95 mg

Faktor koreksi
= 13,95 + 10
900

x 11,628

= 13,95 + 0,1292
= 14,0792 mg

% disolusi = 14,0792 x 100%

250
= 5,63 %
15 0,0531 A
0,0531

= 0,005x 0,036

= 0,0531 + 0,036
0,0005
= 17,82 g/mL

Dalam 1000 mL larutan

= 17,82 g/mL x 900 mL
= 16038 g
= 16,038 mg

Faktor koreksi
= 16,038 + 10

x 14,0792

900
= 16,038 + 0,1564
= 16,1944 mg

% disolusi = 16,1944 x 100%

250
= 6,48%
30 0,0596 A
0,0596

= 0,005x 0,036

= 0,2030 + 0,036
0,005
= 19,12 g/mL

Dalam 1000 mL larutan

= 19,12 g/mL x 900 mL
= 17208 g
= 17,208 mg

Faktor koreksi
= 17,208 + 10

x 16,1944

900
= 17,208 + 0,1799
= 17,3789 mg

% disolusi = 17,3789 x 100%

250
= 6,88 %
45 0,0684 A
0,0684

= 0,005x 0,036

= 0,0684 + 0,036
0,005
= 20,88 g/mL

Dalam 1000 mL larutan

= 20,88 g/mL x 900 mL
= 18792 g
= 18,792 mg

Faktor koreksi
= 18,792 + 10

x 17,3879

900
= 18,792 + 0,1931
= 18,9851 mg

% disolusi = 18,9851 x 100%

250
= 7,59 %
60 0,0723 A
0,0723

= 0,005x 0,036

= 0,0723 + 0,0367
0,005
= 21,66 g/mL

Dalam 1000 mL larutan

= 21,66 g/mL x 900 mL
= 19494 g
= 19,494 mg

Faktor koreksi
= 19,494 + 10

x 18,9851

900
= 19,494 + 0,21
= 19,704 mg

% disolusi = 19,704 x 100%

250
= 7,88 %

75 0,0798 A
0,0798

= 0,005x 0,036

= 0,0798 + 0,036
0,005
= 23,16 g/mL

Dalam 900 mL larutan

= 23,16 g/mL x 900 mL

= 20844 g
= 20,844 mg

Faktor koreksi
= 20,844 + 10

x 19,704

900
= 20,844 + 0,2189
= 21,0629 mg

% disolusi = 21,0629 x 100%

250
= 8,43%
90 0,0825 A
0,0825

= 0,005x 0,036

= 0,0825 + 0,036
0,005
= 23,7 g/mL

Dalam 900 mL larutan

= 23,7 g/mL x 900 mL
= 21330 g
= 21,33 mg

Faktor koreksi
= 21,33 + 10
900
= 21,33 + 0,234
= 21,564 mg

x 21,0629

% disolusi = 21,564 x 100%

250
= 8,63%
105 0,0938 A
0,0938

= 0, 0,005x 0,036

= 0,0938 + 0,036
0,005
= 25,96 g/mL

Dalam 900 mL larutan

= 25,96 g/mL x 900 mL
= 23364 g
= 23,364 mg

Faktor koreksi
= 23,364 + 10

x 21,564

900
= 23,364 + 0,2396
= 23,6036 mg

% disolusi = 23,6036 x 100%

250
= 9,44 %
120 0,1035 A
0,1035

= 0,005x 0,036

= 0,1035 + 0,036
0,005
= 27,9 g/mL

Dalam 900 mL larutan

= 27,9 g/mL x 900 mL

= 25110 g
= 25,11 mg

Faktor koreksi
= 25,11 + 10

x 23,6036

900
= 25,11 + 0,2623
= 25,2723 mg

% disolusi = 25,3723 x 100%

250
= 10,15 %

150 0,1216 A
0,1216

= 0,005x 0,036

= 0,1216 + 0,036
0,005
= 31,52 g/mL

Dalam 900 mL larutan

= 31,52 g/mL x 900 mL
= 28328 g
= 28,368 mg

Faktor koreksi
= 28,368 + 10

x 25,3723

900
= 28,368 + 0,2819
= 28,6499 mg

% disolusi = 28,6499 x 100%

250

= 11,46 %
180 0,1249 A
0,1249

= 0,005x 0,036

= 0,1249 + 0,036
0,005
= 32,18 g/mL

Dalam 900 mL larutan

= 32,18 g/mL x 900 mL
= 28962 g
= 28,693 mg

Faktor koreksi
= 28,693 + 10

x 28,6499

900
= 28,693 + 0,3183
= 29,2803 mg

% disolusi = 29,2803 x 100%

250
= 11,71 %
210 0,1372 A
0,1372

= 0,005x 0,036

= 0,1372 + 0,036
0,005
= 34,64 g/mL

Dalam 900 mL larutan

= 34,64 g/mL x 900 mL

= 31176 g
= 31,176 mg

Faktor koreksi
= 31,176 + 10

x 29,2803

900
= 31,176 + 0,3253
= 31,5013 mg

% disolusi = 31,5013 x 100%

250
= 12,6 %
240 0,1511 A
0,1511

= 0,005x 0,036

= 0,1511 + 0,036
0,005
= 37,42 g/mL

Dalam 900 mL larutan

= 37,42 g/mL x 900 mL
= 33678 g
= 33,678 mg

Faktor koreksi
= 33,678 + 10

x 31,5013

900
= 33,678 + 0,35
= 34,028 mg

% disolusi = 34,028 x 100%

250
= 13,61 %

270 0,1537 A
0,1537

= 0,005x 0,036

= 0,1537 + 0,036
0,005
= 38,66 g/mL

Dalam 900 mL larutan

= 38,66 g/mL x 900 mL
= 34794 g
= 34,794 mg

Faktor koreksi
= 34,794 + 10

x 34,028

900
= 34,794 + 0,378
= 35,172 mg

% disolusi = 35,712 x 100%

250
= 14,07 %
300 0,165 A
0,165

= 0,005x 0,036

= 0,165 + 0,036
0,005
= 40,2 g/mL

Dalam 900 mL larutan

= 40,2 g/mL x 900 mL

= 36180 g
= 36,18 mg

Faktor koreksi
= 36,18 + 10

x 35,172

900
= 36,18 + 0,3908
= 36,5708 mg

% disolusi = 36,5708 x 100%

250
= 14,63 %
330 0,1719 A
0,1719

= 0,005x 0,036

= 0,1719 + 0,036
0,005
= 41,58 g/mL

Dalam 900 mL larutan

= 41,58 g/mL x 900 mL
= 37422 g
= 37,422 mg

Faktor koreksi
= 37,422 + 10

x 36,5708

900
= 37,422 + 0,3908
= 37,8283 mg

% disolusi = 37,8283 x 100%

250
= 15,13 %

360 0,1932 A
0,1932

= 0,005x 0,036

= 0,1932 + 0,036
0,005
= 45,84 g/mL

Dalam 900 mL larutan

= 45,84 g/mL x 900 mL
= 41256 g
= 41,256 mg

Faktor koreksi
= 41,256 + 10

x 37,8283

900
= 41,256 + 0,4203
= 41,6763 mg

% disolusi = 41,6763 x 100%

250
= 16,67 %
Q1 = 10,308