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ORIGINAL ARTICLE

Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: review and factors affecting their success
Fahad M Alswaidi and Sarah J OBrien
................................................................................................... J Med Screen 2009;16:22 28 DOI: 10.1258/jms.2008.008029

See end of article for authors afliations

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Correspondence to: Fahad M Alswaidi, 81 Brantingham Road, Manchester, M16 8SA, UK; Fahad.Alswaidi@postgrad. manchester.ac.uk; f_alswaidi@hotmail.com Accepted for publication 20 November 2008

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This literature review is a comprehensive summary of premarital ( prenuptial) screening programmes for the most prevalent hereditary haemoglobinopathies, namely thalassaemia and sickle cell disease, and the important infections HIV (human immunodeciency virus) and hepatitis viruses B and C (HBV and HCV). It describes the background to premarital screening programmes and their value in countries where these diseases are endemic. The use of premarital screening worldwide is critically evaluated, including recent experiences in Saudi Arabia, followed by discussion of the outcomes of such programmes. Despite its many benets, premarital testing is not acceptable in some communities for various legal and religious reasons, and other educational and cultural factors may prevent some married couples following the advice given by counsellors. The success of these programmes therefore depends on adequate religious support, government policy, education and counselling. In contrast to premarital screening for haemoglobinopathies, premarital screening for HIV and the hepatitis viruses is still highly controversial, both in terms of ethics and cost-effectiveness. In wealthy countries, premarital hepatitis and HIV testing could become mandatory if at-risk, high-prevalence populations are clearly identied and all ethical issues are adequately addressed.

PREMARITAL TESTING FOR THALASSEMIA AND SICKLE CELL DISEASE Introduction

reventive genetic services based on population screening are now an integral part of maternal and child health programmes in many parts of the world. Mass screening and genetic counselling have been carried out widely, but they are not as effective as antenatal screening programmes. New developments in DNA technology, ultrasound scanning and assaying maternal blood factors greatly increase the potential for improving human health.1 The prevalence of inherited blood disorders in certain parts of the world is high, including the autosomally inherited haemoglobinopathies, thalassaemia and sickle cell disease. Premarital screening aims to identify carriers of the haemoglobin disorders, in order to assess the risk of having children with a severe form of disease. The couple can then choose whether or not to have an affected child. Improved healthcare and management means that the numbers of thalassaemic patients and their life expectancy are increasing, and this places extra demands on healthcare systems, meaning that some countries are unable to deliver optimum treatment to all their affected patients. Effective prevention can maximize the available resources if it is instituted properly, preventing up to 95% of affected births.2 Healthy carriers of beta-thalassemia can be identied
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inexpensively and accurately by a simple blood test. Couples who undergo testing can be informed about genetic risks and given options for reducing risk, including prenatal diagnosis.2

History of premarital screening for thalassaemia and sickle cell disease

Premarital thalassaemia screening was rst carried out in 1975 by Silvestroni and colleagues3 in Latium, Italy, as part of a school prevention programme. Screening for sickle cell anaemia began before this, in Virginia in 1970.4 Nationwide screening programmes also began in Canada, Cyprus, Greece, Italy and the UK during the 1970s, with proven success5 (see Table 1). Until this point, the genetic causes of hemoglobinopathy were understood, but little had been done to prevent them in newborns.18

Global aspects of premarital screening programmes

Premarital testing programmes should also educate couples, providing accurate and unbiased information. They must be available to anyone who wants them and proper diagnostic techniques must be used.19 Informed consent is necessary, as well as guarantees of privacy and treatment for the affected individuals. Premarital programmes are most successful when social, religious, ethnic and cultural factors are all addressed.2
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Table1 Countries with known premarital screening programmes

Country Italy Bahrain Iran Jordan Saudi Arabia United Arab Emirates Tunisia Egypt Spain Portugal Turkey Merlin Denizli Cyprus Canada Greece UK USA Illinois & Louisiana China Taiwan Brazil Palestine Malaysia Johor India Indonesia Maldives Singapore Thailand

Date started 1975 1985 1997 2004 2004 2008 2007 1998 1995 1973 1970s 1975 1970s 1983 1992 1993 2002

Type of screening Thalassaemia (mandatory) Thalassaemia and sickle cell disease (mandatory) Thalassaemia (mandatory) Thalassaemia (mandatory) Thalassaemia and sickle cell disease (mandatory) HIV, hepatitis B and hepatitis C (mandatory) Thalassaemia (mandatory) Thalassaemia Thalassaemia Thalassaemia Thalassaemia (mandatory) & STDs (voluntary) & STDs (voluntary) & STDs (voluntary)

Source Silvestroni et al. 3 Al-Arrayed6 Samavat and Modell7 Hamamya et al. 8 AlHamdan et al. 9 Shalhoub10 Al-Gazali et al. 11 Therese12 Therese12 Therese12 Therese12 Keskina et al. 13 Keskina et al. 13 Angastiniotis14 Tosun et al. 5 Tosun et al. 5 Tosun et al. 5 CDC, MMWR15 Therese12 Chern et al. 16 Therese12 Al-Gazali et al. 11 Khebir et al. 17 WHO Secretariat WHO Secretariat WHO Secretariat WHO Secretariat WHO Secretariat Report2 Report2 Report2 Report2 Report2

Thalassaemia (mandatory) Thalassaemia (mandatory Thalassaemia (mandatory) Thalassaemia, SCD & STDs (voluntary) Thalassaemia (mandatory) Thalassaemia, SCD & STDs (voluntary) STDs including HIV (mandatory), stopped Inherited diseases, HBV & HIV (mandatory till 2003) Thalassaemia (Voluntary) Inherited & STDs (mandatory in some areas) Thalassaemia (mandatory) HIV (Mandatory) Inherited & STDs (voluntary) Inherited & STDs (voluntary) Inherited & STDs (voluntary) Inherited & STDs (voluntary) Inherited & STDs (voluntary)

Beta-Thalassaemia Unknown date HIV, human immunodeciency virus; SCD, sickle cell disease; STDs, sexually transmitted diseases

Angastiniotis and Modell20 classied countries who deliver premarital screening programmes into three categories: (1) Endemic Mediterranean countries in which preventive programmes are long-established, with success rates ( preventive) of 80 100% and optimum treatment via specialist clinics. Developed, industrialized countries in which prevalence is increasing because of migration; these countries can fund screening programmes, but nd it difcult to reach immigrants with certain cultural backgrounds. Developing countries in which there are economic difculties and other health priorities (e.g. infectious disease control), or other religious and cultural constraints20 (see later).

(2)

(3)

In Cyprus, Greece and Italy, premarital screening for thalassemia has been normal practice for a long time because consanguinity is high. Similar preventive programmes have been introduced in Bahrain, China, India, the Islamic Republic of Iran, Indonesia, Malaysia, the Maldives, Singapore and Thailand, and recently in Saudi Arabia and United Arab Emirates. In the UK, Northern Ireland and other northwest European countries, prenatal diagnosis is available and abortion is a prevention strategy.2
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In China, couples who wish to marry are extensively tested, including physical examination. They are given premarital health instructions and counselling in the form of watching videotapes of the type of child they might conceive after which appropriate measures are taken. This approach has been strongly criticized in terms of human rights, control, oppression and eugenics, even though the value of vigilant premarital screening is acknowledged.21 In Lebanon, thalassaemia patients are managed in chronic-care centres in collaboration with the ministries of Social Affairs and Public Health. Their screening programme includes providing information, training health professionals and developing training materials, with priority given to disseminating knowledge and increasing public awareness.22 Tosun et al. 5 studied the premarital haemoglobinopathy screening programmes in Mersin, Turkey, where consanguinity is 30%. If the man and the woman are both carriers, results are given condentially and they are counselled about their options, including prenatal diagnosis. In Saudi Arabia, premarital testing for haemoglobinopathies is mandatory.9 The results of at-risk couples are treated in the same way as in Turkey. Prenatal diagnosis is not offered, however, as discussed later.9
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Role of culture and education in the success of screening programmes

Consanguinity refers to relationships by blood or common ancestry, in which the chances of offspring inheriting a recessive allele for a disease are increased; the closer the relationship, the greater the risk. Marriages between members of the same tribe or extended family group are favoured in some cultures, including those between rst cousins. Consanguineous marriages are uncommon in Western countries. Marriage between rst cousins is forbidden by the Orthodox Church and Roman Catholic Church, and may be seen as incestuous in the United States. Personal characteristics including socioeconomic status have implications for the outcome of premarital screening programmes. Education of the couples who are to be screened is extremely important and it is essential to educate all members of the screening team (laboratory technologists, nurse practitioners, physicians, counsellors, outreach workers and social workers). According to Schmidt,23 sufcient planning in the educational area before the rst blood sample is drawn can avoid failures of the programme. The meaning of the term carrier status should be made known to members of the public long before they get married. For successful public education, governments and government organizations must cooperate, as well as community and religious leaders, school parent organizations and health personnel.5 A study by Eshra and colleagues24 based in Egypt revealed gaps in knowledge regarding premarital screening, even among educated people. These people acquired their knowledge from the mass media and medical personnel. People who responded to information about premarital screening had favourable attitudes towards premarital counselling and examination of consanguineous marriages, possibly relating to social changes, declining illiteracy, increasing economic pressures, increasing numbers of nuclear families and longer waiting times before starting a family.24 People with a negative attitude towards these tests were mostly unmarried males. Eshra and colleagues24 therefore suggested that education programmes about the benets of premarital examination should target unmarried males, so they can make informed choices about unmarried females and consanguineous marriages. Religious beliefs restrict the success of screening programmes in some communities. In Southern Iran, premarital screening has been mandatory for 10 years, yet high-risk couples still get married and give birth to children homozygous for betathalassaemia. Often this is because of religious and traditional cultural restraints25; in the case of Islam, consanguineous marriages are permitted, so thalassemia persists in some parts of the community, making the programme redundant.25 Some people believe that their fate is determined by God and therefore accept the risk of having a sick child. A recent report in The Jordan Times 26 showed that many Jordanians view the results of their unions as fate. One interviewee stated: All my ten children are disabled; they will get their reward in heaven. On the contrary, there are many teachings in Islamic culture that promote healthy marriage and the role of counselling.27 AlKhaldi et al. 28 evaluated the attitude of health-science students in Saudi Arabia towards premarital screening and

counselling. Most students had a positive attitude, but around 25% refused testing and counselling according to their interpretation of Islamic principles. Awatif29 studied attitudes among female students in King Saud University, discovering that 86% of them felt positively about premarital testing. El-Hazmi30 assessed attitudes in a community-based study and found 94% of participants considered premarital testing and counselling to be important in preventing genetic blood diseases; 87% thought testing should be mandatory. The Saudi community clearly shows awareness of premarital testing and its value; however when AlHamdan et al. 9 studied the outcome of the rst 2 years of the Saudi screening programme, they found that about 90% of highrisk couples still got married despite knowing their risk of having a sick child. This undermines the high level of awareness identied in other studies. One possible explanation is that both AlKhaldi et al. 28 and Awatif29 focused on the opinions of university students and El-Hazmis community study30 was among university students and people attending scientic meetings and health centres. None of these studies was truly representative of the Saudi population as a whole and therefore the results cannot be generalized. Reports by Karimi et al.,25 Monaghan26 and AlKhaldi et al. 28 were from three different Islamic countries, and all three provided evidence that religious beliefs could be obstacles to the success of premarital screening programmes, regardless of other factors such as education level. The same conclusions were reported long ago in other (non-Muslim) communities. In 1981, Angastiniotis and Hadjiminas14 stated that support from the Church was the main reason for the success of screening programmes in Cyprus and Greece.

Counselling
Genetic counselling is the process by which an individual or a family obtains information about a genetic condition that may affect them, so that they can make appropriate decisions about marriage, reproduction and health management.27 Genetic counselling protects the autonomy of the couple, fullling their right to be fully informed about the disorder and all available options.2 Although premarital tests for haemoglobinopathies are reliable and useful, not everyone with these genes responds to counselling. Neal-Cooper and Scott4 reported that young couples concerns about producing a child with sickle cell disease are often offset by their strong desire to have children regardless of risk. The researchers suggested that at-risk couples should be contacted directly by counsellors and encouraged to undertake education and counselling. Prevention and treatment of genetic diseases is virtually impossible.1 Studies of patient perspectives about premarital examinations reveal a need for physicians to offer counselling for various health problems before the patient asks, so they can turn down unwanted help rather bring up sensitive issues.31 Screening programmes that inform about the risks associated with child bearing should be performed well before child-bearing age. Unfortunately, premarital screening often comes too late for couples to change their opinions about marriage based on their haemoglobin phenotype, because by this point they are already committed to their relationship. Furthermore, it may be taboo for a woman

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to reject marriage for these reasons, and it may affect her social life, preventing her from ever getting married. One successful approach is solution-focused premarital counselling. Murray and Murray32 discuss how this focuses on a couples resources, helping them to develop a shared vision for the marriage. Background information about premarital counselling and solution-focused therapy provide a framework in which intervention strategies in those conrmed with positive status for a disease can be developed. These solution-oriented interventions include solution-oriented questions and feedback, as well as a Couples Resource Map (CRM) which depicts the support available to the couple from various personal, relationship and contextual resources.33 The available choices include avoidance of marriage, reproductive options for those who proceed with the marriage following prenatal diagnosis, adoption of the affected child, donation of sperm, ova or a pre-embryo from an unaffected individual, and pre-implantation diagnosis.26 Choosing the best option depends on availability, cost, and local regulations and religious rules. For example, in Saudi Arabia adoption of children is prohibited on religious grounds and prenatal diagnosis is useless because abortion is forbidden unless the fetus is malformed. However, pre-implantation diagnosis is permitted and affordable. Thus the success of genetic counselling depends on the approach adopted by the counsellor as well as the education and attitude of the couple. Screening programmes must be equitable, accessible and understood by the target population, but most importantly they must comply with the prevailing cultural, ethnic, economic and societal values.

importance.38 This is why it is so important to examine the options for prevention and management of genetic disorders and their ethical and (country)-policy-related implications. In 2004, the Saudi Arabian Government implemented compulsory premarital screening aimed at decreasing the incidence of haemoglobinopathies. It was implemented by the Ministry of Health, which is responsible for providing free health care to the entire population, and the decision to make testing mandatory was based on discussions with numerous technical, religious and social organizations. Currently, there are over one hundred health reception centres, 70 blood-testing laboratories and 20 genetic counselling and education clinics in the country. Both screening and counselling are free of charge. A specialist centre in Riyadh, in association with King Faisal Specialist Hospital, trains all the health personnel who work on the programme. The carefully formulated guidelines are regularly updated.9 AlHamdan and colleagues9 assessed the premarital screening programme two years after it became mandatory. Everyone in Saudi Arabia had good access to the programme. High prevalence of carrier status was reported predominantly in the eastern and south western regions of the country, but (as mentioned above) 90% of couples detected as carriers did not follow the advice they were given and went ahead with their marriages. This result requires evaluation and revision of the programme by the Saudi health authority in order to achieve its goals as AlHamdan said.

Premarital testing in Saudi Arabia and other Arabian countries

Genetic and congenital disorders are common in Arab countries, contributing greatly to infant mortality and morbidity. Common among these diseases are the haemoglobinopathies and glucose-6-phosphatase deciency.11 In the rst half of the twentieth century, the governments of countries like Egypt, Syrian Arab Republic, Lebanon, Tunisia, and Morocco began promoting optional premarital examinations. To begin with, there were no methods for detecting disease carriers, so hereditary diseases and consanguinity were little affected. Medical certicates were often provided without complete medical check-ups.34 As detection became possible, the burden of screening was taken up by the Governments of Egypt, Lebanon, Bahrain, Saudi Arabia and United Arab Emirates in order to establish appropriate screening techniques and policies. Premarital screening is essential for changing attitudes towards consanguineous marriage35 particularly in places where consanguineous and tribal marriages are common, resulting in a high incidence of genetic disorders.36 Such marriages are rare in Western societies, often restricted by civil legislation and religious beliefs37 but it has been estimated that 2560% of all marriages in Arab regions are consanguineous,11 with a high incidence of rst-cousin marriage. In fact, marriage within the family is encouraged in many parts of Asia and Africa and the east-Mediterranean region, which is mainly occupied by Arabs and Muslims for whom religious considerations are of paramount
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PREMARITAL SCREENING OF HIV HBV AND HCV , Epidemiology of HIV HBVand HCV ,
Currently, there are about 4.1 million people with HIV infection worldwide; 95% of them are in developing countries, generally in sub-Saharan Africa and Southeast Asia.39 Approximately 1.8 billion people have serologic evidence of HBV infection and 350 million have a chronic infection. At least 500,000 of them die of liver malignancy and cirrhosis.40 The World Health Organization (WHO) estimates 170 million people around the world are infected with HCV.41 Prevalence varies widely, with Egypt having the highest of 22%. Healthy blood donors reveal infection rates of 0.01 0.02% in the UK and northern Europe, 1 1.5% in southern Europe, and 6.5% in parts of equatorial Africa.41 According to the Centres for Disease Control and Prevention, 1.8% of the US population is positive for anti-HCV, with 8000 10,000 deaths each year caused by HCV infection.41 Unfortunately, information about the prevalence of these diseases among the specic target groups is not available. In 2004, the Saudi Ministry of Health announced the total number of HIV carriers was about 11,000, of which 2005 were Saudis, giving a prevalence of about 0.011% for the Saudi population (18 million). Estimates for the prevalence of HBV and HCV in young Saudi adults are available, but not specically for the group targeted by screening programmes. El-Hazmi42 found prevalence rates of 1.4% for hepatitis B surface antigen (HBsAg) and 0.2% for anti-HCV among Saudi blood donors in Riyadh, and prevalences of 2.0% and 1.6%, respectively, among non-Saudi blood donors. Another study by Bashawri and colleagues43 found a steady decrease
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in HBsAg (from 2.58 to 1.67%) and antiHCV (from 1.04 to 0.59%) in the Eastern region among blood donors between 1998 and 2001. However, Saudi Arabia began mandatory premarital screening for hepatitis B and C viruses and HIV in the beginning of 2008.10 Adding these new tests to the Saudi mandatory premarital screening programme means that about a quarter of million individuals must undergo HIV, HBV and HCV testing annually10, which is not cost-effective due to the low prevalence of these diseases especially HIV. As a Saudi citizen, the author of this paper appreciates the rationale for adding these new tests, namely the massive public and media pressure on the government. At the time of writing, however, the current programme has been running for less than a year, and no formal reports have yet been released. This programme will denitely enable the Saudi health authority to clearly estimate the epidemiologic indicators for these infections or any other health problems among Saudis in the future.

Negative aspects of the screening programmes

Mandatory premarital screening for these infections would involve assessing many new couples each year, with huge nancial implications.46 Petersen and White48 evaluated HIV seroprevalence premaritally in eight areas of the US; with rate estimates of 0.4% in women and 0.1% in men. These rates were much higher than those obtained by routine tests among blood donors. They also found that the number of marriage licenses issued was not greatly affected, and concluded that mandatory premarital screening would be more expensive than other HIV prevention programmes, and have a limited impact on the epidemic. These ndings concur with those of an earlier study46 in which public education, counselling and discretionary testing reduced the spread of HIV infection more effectively than premarital screening. Petersen and White48 proposed some more economical and effective alternative strategies: testing HIV status in pregnant women and treating affected fetuses, and increasing the availability of drug treatments to high-risk groups like intravenous drug users. Turnock and Kelly47 evaluated mandatory premarital HIV testing in Illinois (there was only one other similar programme in the US, in Louisiana; both were discontinued within 2 years).51 This enforcement generated many legal concerns, not least regarding the infringement of fundamental liberty, the right to marry and the implications of involuntary withdrawal of blood.52 The study concluded that these mandatory tests were not a cost-effective way to control HIV infection; the cost of running the programme for 6 months was $2.5 million (or $312,000 per seropositive person). The number of marriage licenses issued in Illinois decreased by 22.5%, but the number of licenses issued to Illinois residents in surrounding states increased signicantly, meaning some couples moved to other states to marry.53

The need for premarital screening of HIV , HBVand HCV

Heterosexual sex and perinatal transmission can affect the fetus, resulting in infections of the newborn. Newborns infected with HIV will eventually develop AIDS (acquired immunodeciency syndrome). Although detection of HIV in the mother and providing anti-HIV therapy is common, success rates are unclear and there are nancial and medical constraints. In Belarus, Kazakhstan, the Republic of Moldova, the Russian Federation and Ukraine, massive outbreaks have been reported among injecting drug users. Transmission of HIV to non-injecting sexual partners occurs, as well as recipients of blood and other tissues, thus increasing overall prevalence. Hepatitis viruses (HBV and HCV) are also transmitted among drug users; in fact, hepatitis epidemics among drug users do precede HIV infection. Prevalence of HCV in injection drug users is far greater than HIV, indicating that HCV has greater transmissibility via blood.44 Perinatal hepatitis is not always symptomatic but there is a high risk of infection becoming chronic, and there are only a limited number of medications for treating HBV and HCV infections. An effective vaccine for HBV is now available,45 forming an essential part of vaccination programmes around the world. These important infections are a heavy nancial burden for health services. In the US, annual costs associated with the treatment of HCV infection alone exceed $600 million.41

Positive aspects of the screening programmes

Altman et al. 50 conducted a study to determine the effectiveness of premarital testing in New Jersey, USA. They found that seroprevalence in unmarried couples was 0.55 0.62%, much more than other earlier estimates. Therefore they recommended voluntary HIV-1 testing and counselling for marriage applicants. Some studies show mandatory premarital testing to be cost-effective; in the US, McKay and Phillips49 predicted savings of $70,000 to $127,000 for every case of HIV infection prevented. They found a statistically signicant cost benet ratio of between 3.1 and 28.2 in many scenarios. Khebir et al. 17 evaluated a premarital screening programme in Johor State (Malaysia) over 3 years. They reported a positivity rate of 0.17% for premarital screening compared with a positivity rate of 0.05% for antenatal screening. The number of marriage applications actually increased and public awareness of HIV was raised, thus improving the chances of early detection. This programme uses a newer, rapid and cheap but highly sensitive and specic screening test (SD Bioline HIV-1/2 3.0; Standard Diagnostics Inc. Kyonggi-do, South Korea) and the screening and conrmatory tests are free to the public. Adibi et al. 40 assessed the economics of preventing HBV transmission in unmarried people in Iran, where cultural
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Evaluation of screening programmes for HIV in various countries

Sexual and vertical (from mother to fetus) modes of transmission of HIV are well known; therefore the WHO recommends voluntary screening programmes together with counselling and education services in countries with high HIV prevalence rates.44 Several studies have examined the acceptability and benets of these screening programmes, revealing important issues, both negative46 48 and positive17,49,50 as described below.
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inuences are strong and HBV infection is endemic. They reported that premarital HBV testing is cost effective.

Factors influencing the success of screening programmes for HIV HBVand HCV ,
Although the prevalence of these infections seems to be the most important factor when implementing screening programmes, the countrys resources, availability of medical care, education, and public awareness are also important. Some international associations (e.g. Bill Clinton HIV Initiative and the United Nations AIDS programme) have suggested that HIV screening should be mandatory in countries with prevalence of 5% or more.54 In regions where the prevalence of HIV, HBV and HCV is high, knowledge about the diseases and uptake of voluntary counselling and testing is low.55 This is probably because these infection rates are greater in developing and underdeveloped countries where literacy and levels of understanding are low. Culture and individual attitudes also have a role in the success of testing.55 57 Iliyasu et al. 55 reported that knowledge of HIV in Nigeria is low, especially in rural areas, even though it has the third highest population of people living with HIV. Many Nigerians did not know the cause of AIDS or the modes of transmission, and those who knew about the disease rejected voluntary counselling and testing because of misconceptions and fear, gaps in knowledge and limited access to the services. Formal education, female gender and HIV knowledge predicted a positive attitude. The impact of culture cannot be underestimated. Luginaah et al. 56 reported that HIV testing has a far-reaching social impact, especially for people planning to marry, which extends beyond individuals and couples in certain communities where values may clash with the concept of premarital HIV testing and there are issues of condentiality. Other than Saudi Arabia, only China implements mandatory premarital testing for HBV and this is because the prevalence of HBsAg carriers is high (10%).12 Mandatory premarital screening for HCV is only reported in Saudi Arabia as well.10 Routine testing for the hepatitis viruses and HIV is undertaken by many countries, but usually before blood donation, before surgical procedures, in people who are admitted to hospital and in prisoners. Mandatory pre-military recruitment and pre-employment screening are now common. When Adibi et al. 57 evaluated the attitudes of young adults in Iran towards premarital HBV screening, male sex and higher education level were associated with more positive attitudes. They inferred that a universal premarital HBV screening programme would be highly acceptable in Iran.

their introduction in the early 1970s, some premarital screening programmes have become widely accepted and highly valued in preventive healthcare, so much so that many countries have made them mandatory. Their value to public health is widely acknowledged. Yet, not all screening programmes have shared this degree of success. Some very strong social factors inuence the acceptability of preventive programmes, not least among them religious beliefs, cultural norms, traditions, literacy and education level, government policies and the attitudes of individual couples. For mandatory infection screening programmes to be successful, every one of these factors needs to be addressed. Experiences from some Islamic countries indicate that the way in which some individuals misinterpret their religion creates a signicant obstacle to the success of screening programmes in Muslim communities. HIV and hepatitis infections are now prevalent in epidemic proportions and are easily transmitted to sexual partners and to newborns. They are not curable, and mortality and morbidity rates are high. For these reasons alone, they are strong candidates for inclusion in premarital screening programmes. Currently, routine screening for these important viral diseases is mainly conducted among blood and tissue donors. The situation is only changing slowly. China and Saudi Arabia have started premarital screening for HBV and Iran is considering including it as part of its own premarital screening programme. Mandatory premarital screening for HIV is a different issue altogether. It has been tried in some countries, such as the USA, Malaysia and Saudi Arabia, but with very limited success in USA. Enforcement is still highly controversial, and raises serious ethical and cost-effectiveness issues. More outcome data from Malaysia and Saudi Arabia, among other countries, will do much to increase the body of evidence on these matters. In developed and committed countries, mandatory premarital screening does have the potential to succeed as long as the target population is clearly identied and all ethical issues (including condentiality of the results), religious, cultural and human rights and concerns about proper post-diagnostic management are fully addressed.

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Authors afliations Fahad M Alswaidi, Epidemiology PhD student, The University of Manchester, School of Translational Medicine, Occupational and Environmental Health Research Group Stopford Building, Oxford Road, M13 9PT, UK Sarah J OBrien, Professor of Health Sciences and Epidemiology/ Honorary Consultant, The University of Manchester, School of Translational Medicine, Occupational and Environmental Health Research Group, Stopford Building, Oxford Road, M13 9PT, UK

CONCLUSION
Thalassemia and sickle cell disease are common, incurable, autosomal recessive inheritable haemoglobinopathies that cause signicant morbidity and mortality and impose a heavy nancial burden on society. A simple blood test before marriage can easily detect carriers of these diseases, to inform couples about their chances of producing affected children and ensure they receive appropriate advice. Since
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ACKNOWLEDGEMENTS
We are grateful to the journals reviewers for their valuable comments which guided the revision of the manuscript.

REFERENCES
1 Kuliev AM, Modell B. Problems in the control of genetic disorders. Biomed Sci 1990;1:3 17

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2 3 4 5 6 7 8 9 10 11 12 13 14 15 WHO Secretariat Report. Thalassemia and other hemoglobinopathies. Provisional agenda item 5.2, EB 118(5). Geneva: World Health Organization 2006 Silvestroni E, Bianco I, Graziani B, Carboni C, DArca SU. First premarital screening of thalassaemia carriers in intermediate schools in Latium. J Med Genet 1978;15:202 7 Neal-Cooper F, Scott RB. Genetic counselling in sickle cell anemia: experiences with couples at risk. Public Health Rep 1988:103:174 8 Tosun F, Bilgin A, Kizilok A. Five-year evaluation of premarital screening program for hemoglobinopathies in the province of Mersin, Turkey. Turk J Hematol 2006;23:84 89 Al-Arrayed SS. Review of the spectrum of genetic diseases in Bahrain. Eastern Mediterranean Health Journal 1999:5:1114 120 Samavat A, Modell B. (2004). Iranian national thalassaemia screening programme. BMJ 329:1134 1137 Hamamya H, Al-Haitb S, Alwanc A, Ajlounia K. Jordan: Communities and community genetics. Commun Genet 2007;10:52 60 AlHamdan NA, AlMazrou YY, AlSwaidi FM, Choudary AJ. Premarital screening for thalassemia and sickle cell disease in Saudi Arabia. Genet Med 2007;9:372 7 Shalhoub L. Arab News 9 January 2008. Available at: http://www. arabnews.com/?page=1&section=0&article=105463&d=9&m= 1&y=2008 Al-Gazali L, Hamamy H, Al-Arrayad S. Genetic disorders in the Arab World. BMJ 2006;333:831 4 Therese H. Getting married in China: Pass the medical rst. BMJ 2003;326:277 9 Keskina A, Turk T, Polat A, Koyuncu H, Saracoglu B. Premarital screening of beta-thalassemia trait in the province of Denizli, Turkey. Acta Haematol 2000;104:31 3 Angastiniotis MA, Hadjiminas MG. Prevention of thalassaemia in Cyprus. Lancet 1981;1:369 71 Centres for Diseases Control and Prevention, MMWR. Perspectives in Disease Prevention and Health Promotion Public Health Service Guidelines for Counselling and Antibody Testing to Prevent HIV Infection and AIDS. August 14, 1987;36(31):509 15. Retrieved on 23 November 2007 from: http://www.cdc.gov/mmwr/preview/mmwrhtml/00015088.htm (last accessed November 2008) Chern JP, Lin KH, Lu MY, et al. Beta-thalassemia major births after National Screening Program in Taiwan. Pediatr Blood Canc 2007;50:58 61 Khebir BV, Adam MA, Daud AR, Shahrom CM. Premarital HIV screening in Johor (2002 2004). Med J Malaysia 2007;62:19 22 Naylor EW. Genetic screening and genetic counselling: knowledge, attitudes, and practices in two groups of family planning professionals. Soc Biol Winter 1975;22:304 14 Schumm WR, West DR. Development of three new scales for assessing clients perspectives on premarital counselling. Psychol Rep 2002;88(3Pt2):1071 4 Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann NY Acad Sci 1998;850:251 69 Hesketh T. Getting married in China: pass the medical rst. BMJ 2003;326:277 9 Inati A, Zeineh N, Ismaeel H, et al. Beta-thalassemia: the Lebanese experience. Clin Lab 2006;28:217 27 Schmidt RM. Hemoglobinopathy screening: approaches to diagnosis, education and counselling. Am J Publ Hlth 1974;64:799 804 Eshra DK, Dorgham LS, el-Sherbini AF. Knowledge and attitudes towards premarital counselling and examination. J Egypt Publ Hlth Assoc 1989;64(1/2):1 15 Karimi M, Jamalian N, Yarmohammadi H, Askarnejad A, Afrasiabi A, Hashemi A. Premarital screening for beta-thalassaemia in Southern Iran: options for improving the programme. J Med Screen 2007;14:62 6 Monaghan S. Genetics: For better or for worse. Middle East Health 2007:19 26. Available at: http://216.230.204.101/mehealth/ sep03_article1.pdf (last accessed November 2008) Albar MA. Counselling about genetic disease: an Islamic perspective. East Mediterr Hlth J 1999;5:1129 33 AlKhaldi YM, Al-Sharif AI, Sadiq AA, Ziady HH. Attitudes to premarital counselling among students of Abha Health Sciences College. Saudi Med J (Aug 2002);23:986 90 Awatif A. Perception of female students of King Saud University towards premarital screening. J Fam Commun Med 2006;13:83 8 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57

Alswaidi and OBrien

El-Hazmi MA. Pre-marital examination as a method of prevention from blood genetic disorders. Community views. Saudi Med J 2006;27:1291 5 Schmitt EP. The premarital exam: a patient perspective. Fam Pract Res J 1990;10:133 41 Murray CE, Murray Jr, TL Solution-focused premarital counselling: helping couples build a vision for their marriage. J Marital Fam Ther 2004;30:349 58 Christine EM. Couples Resource Map Scales study. University of North Carolina (USA). Available at: http://www.couplesresourcemap.org/ (last accessed November 2008) World Health Organization. Hereditary anaemia: genetic basis, clinical features, diagnosis and treatment. Bull Wrld Hlth Org 1982;60:643 60 Abdel-Meguid N, Zaki MS, Hammad SA. Premarital genetic investigations: effect of genetic counselling. East Mediterr Hlth J 2000;6:652 60 Al-Odaib AN, Abu-Amero KK, Ozand PT, Al-Hellani AM. A new era for preventive genetic programs in the Arabian Peninsula. Saudi Med J 2003;24:1168 75 Port KE, Mountain H, Nelson J, Bittles AH. Changing prole of couples seeking genetic counselling for consanguinity in Australia. Am J Med Genet A 2005;132:159 63 Albar MA. Ethical considerations in the prevention and management of genetic disorders with special emphasis on religious considerations. Saudi Med J 2002;23:627 32 Dubin J. HIV infection and AIDS. Available at: http://www.emedicine. com/emerg/topic253.htm (last accessed November 2008) Adibi P, Rezailashkajani M, Roshandel D. An economic analysis of premarriage prevention of hepatitis B transmission in Iran. BMC Infect Dis 2004;4:31 Mukherjee S, Dhawan VK. Hepatitis C. Available at: http://www. emedicine.com/med/topic993.htm (last accessed November 2008) El-Hazmi MM. Prevalence of HBV, HCV, HIV-1/ 2 and HTLV-I/II infections among blood donors in teaching hospitals in the central region of Saudi Arabia. Saudi Med J 2004;25:26 33 Bashawri LA, Fawaz NA, Ahmad MS, Qadi AA, Almawi WY. Prevalence of seromarkers of HBV and HCV among blood donors in eastern Saudi Arabia, 1998 2001. Clin Lab Haematol 2004;26:225 8 World Health Organization. Workshop on quality assurance of HIV and hepatitis testing. Kiev, Ukraine, 24 26 September 2003 World Health Organization. Hepatitis B Factsheet. Available at: http:// www.who.int/mediacentre/factsheets/fs204/en/ (last accessed November 2008) Cleary PD, Barry MJ, Mayer KH, et al. Compulsory premarital screening for the human immunodeciency virus. Technical and public health considerations. J Am Med Assoc 1987;258:1757 Turnock BJ, Kelly CJ. Mandatory premarital testing for human immunodeciency virus. The Illinois experience. J Am Med Assoc 1989;261:3415 8 Petersen LR, White CR. Premarital screening for antibodies to human immunodeciency virus type 1 in the United States. The Premarital Screening Study Group. Am J Publ Hlth 1990:80:1087 90 McKay NL, Phillips KM. An economic evaluation of mandatory premarital testing for HIV. Inquiry 1991:28:236 48 Altman R, Shahied SI, Pizzuti W, Brandon DN, Anderson L, Freund C. Premarital HIV-1 testing in New Jersey. J Acq Immun Dec Synd 1992;5:7 11 McKillip J. The effect of mandatory premarital HIV testing on marriage: The case of Illinois. Am J Publ Hlth 1991;81:650 53 Lisko EA. Mandatory premarital HIV testing. Health Law and Policy Institute. Available at: http://www.law.uh.edu/healthlaw/perspectives/ HIV AIDS/990226Premarital.html (last accessed November 2008) Wilkerson I. Illinois legislature repeals requirement for Prenuptial AIDS tests. The New York Times National Sunday June 25, 1989 Editorial. HIV: Compulsory testing and falling incidence? Lancet 2006;367:1118 Iliyasu Z, Abubakar IS, Kabir M, Aliyu MH. Knowledge of HIV/AIDS and attitude towards voluntary counselling and testing among adults. J Natl Med Assoc 2006;98:1917 22 Luginaah IN, Yiridoe EK, Taabazuing MM. From mandatory to voluntary testing: balancing human rights, religious and cultural values, and HIV/ AIDS prevention in Ghana. Soc Sci Med 2006;61:1689 700 Adibi P, Saeid H, Massod M. Attitudes towards premarital screening for hepatitis B virus infection in Iran. J Med Screen 2007;14:43 5

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Journal of Medical Screening

2009

Volume 16

Number 1

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