MVRKGEKKLAKPATTKAANPQPRRRANNRRRSNRTDAPVSKASTVTGFGRGTN
MVRKGEKKLAKPATTKAANPQPRRRANNRRRSNRTDAPVSKASTVTGFGRGTN MVRKGDKKLAKPPTTKAANSQPRRRATQRRRSGRADAPLAKASTITGFGRATN
D 75-Catalytic domain DxxDxD motif (Ca ligand during virion formation
54
135
2001Nag
Tsushima
136
216
RGNNV
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
DGNNV
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
SGNNV SGWak97
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
RBNNV-Korea
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
DlEV
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
2001Nag Tsushima
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
SJNNV
DHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSTGKEQRLTSPGRLVLLCVGSNTDVVNVSVMCRWSVRLSVPSLETP
TPNNV
DHTFDAIQATRGAVVAKWWESRTVRPQYARTLLWTSTGKEQRLTSPGRLILLCVGSNTDVVNVSVLCRWSVRLSVPSLETP
BFNNV
DHTFDAIQATRGAVVAKWWESRTIRPQYARALLWTSVGKEQRLTSPGRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETP
PDG motif: neutralizing epitopes 235 that determine viral infectivity 217 Variable region 300 RGNNV EETTAPIMTQGSLYNDS- -LSTNDFKSILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFR DGNNV EETTAPIMTQGSLYNDS- -LSTNDFKSILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFR SGNNV SGWak97 EETTAPIMTQGSLYNDS-LSTNDFKSILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFR RBNNV-Korea EETTAPIMTQGSLYNDS- -LSTNDFKSILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFR DlEV EETTAPIMTQGSLYNDS- -LSTNDFKSILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFR 2001Nag Tsushima EETTAPIMTQGSLYNDS-LSTNDFKSILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFR SJNNV EDTTAPITTQAPLHNDSINNGYTGFRSILLGATQLDLAPANAVFVTDKPLPIDYNLGVGDVDRAVYWHLRKKAGDTQVPAGYFD TPNNV EETFAPITSQGPLYNDSITTATSGFRSILLGSGQLDIAPPGTVYSIDRPLSIDYNLGVGDVDRAVYWHLLKKKGDPNNPAGFLD BFNNV EDTFAPILTLGPLYNDS- -LAANDFKSILLGSTQLDIAPEGAVYSLDRPLSIDYSLGTGDVDRAVYWHVKKVAGNVGAPAGWFH
316 301 Variable region 338 (340) WGIWDNFNKTFADGVAYYSDEQPRQILLPVGTVCTRVDSEN RGNNV WGIWDNFNKTFTDGVAYYSDEQPRQILLPVGTVCTRVDSEN DGNNV SGNNV SGWak97 WGIWDNFNKTFADGVAYYSDEQPRQILLPVGTVCTRVDSEN RBNNV-Korea WGIWDNFNKTFADGVAYYSDEQPRQILLPVGTVCTRVDSEN WGIWDNFNKTFTDGVAYYSDEQPRQILLPVGTVCTRVDSEN DlEV 2001Nag Tsushima WGIWDNFNKTFTDGVAYYSDEQPRQILLPVGTVCTRVDSEN WGLWDDFNKTFTVGAPYYSDQQPRQILLPAGTLFTRVDSEN SJNNV WGLWDDFNKVFTTGVAYYSDQQPRQILLPVGT TPNNV BFNNV WGLWDNFNKTFTQGVAYYSDAQPRQILLPVGT 2001NagTsushima..Our lab strain MVRKGEKKLAKPATTKAANPQPRRRANNRRRSNRTDAPVSKASTVTGFGRGTNDVHLSGM SRISQAVLPAGTGTDGYVVVDATIVPDLLPRLGHAARIFQRYAVETLEFEIQPMCPANTG GGYVAGFLPDPTDNDHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSSGKEQRLTSP GRLILLCVGNNTDVVNVSVLCRWSVRLSVPSLETPEETTAPIMTQGSLYNDSLSTNDFKS ILLGSTPLDIAPDGAVFQLDRPLSIDYSLGTGDVDRAVYWHLKKFAGNAGTPAGWFRWGI WDNFNKTFTDGVAYYSDEQPRQILLPVGTVCTRVDSEN