CONNECTIVE REPAIR

LP 7
Healing:
The healing of lesions from inflammatory focus is characterized by 2 types
of processes:
 regeneration
 connective repair

REGENERATION :
Represents the morphologic and functional recovery of the injured tissue
with the same type of tissue (in injured tissues that kept the capacity of
dividing).

After the capacity of cellular divission we can distinguish three types of

cellular lesions:
• Labile cells (capacity of regeneration or continue multiplication) - epidermis

• Stable cells (the capacity of de regeneration is limited) - liver

• Permanent cells (they don’t have the capacity of divission) - miocardium

 CONNECTIVE REPAIR
 Represents the morphological and functional recovery of the injuried tissue by
fibrous tissue.

( in large tissue destructions: inflammation, necrosis)

The characteristic element of connective repair is:

Granulation tissue (connective-vascular tissue).

It could be:
 YOUNG

 MATURE

 FIBROUS
 Examples of connective repair

Connective organization

• Replacement of inflammatory exudate by granulation tissue

• Connective organization of a thrombus
• Connective organization of miocardial infarction

Connective encapsulation

Is specific to the large lessions that could not be repaired by

connective organization

At the periphery of these large areas (abscess, hematoma) there is a

connective-vascular tissue that by maturation forms a connective
capsule that limits the affected area by the rest of the tissue
Young granulation tissue
(Vascular granulation tissue)

Microscopically:

 New cappilaries
(with prominent endotelium);

 Inflamatory cells
(neutrophils, macrophages,
lymfocytes) and eritrocytes.

Rare fibroblasts;

Eosinophilic transudate.

Coloraţia HE
MATURE GRANULATION
TISSUE
(fibro-vascular granulation tissue)

Connective organization
of myocardial infarction

Microscopically

 A decreased number of
new capillaries;

 A decreased number
of inflammatory cells
(lymphocytes, macrophages).

Numerous fibroblasts.
Coloraţia HE
MATURE
GRANULATION
TISSUE
(fibro-vascular
granulation tissue)

Connective
Organization of
a thrombus

Oclusive thrombus
replased by a
granulation tissue
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FIBROUS TISSUE
(Fibrous granulation tissue)

Wall of liver
chronic abscess

Microscopically

 Rare vessels

 Numerous fibrocytes;

 Collagen fibers.

Coloraţia HE