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DAFTAR ISI

DAFTAR ISI ..................................................................................................

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DAFTAR TABEL .........................................................................................

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DAFTAR GAMBAR .....................................................................................

BAB I

BAB II

BAB III

PENDAHULUAN
1. 1

Latar Belakang ....................................................................

1. 2

Perumusan Masalah ............................................................

1. 3

Hipotesis Penelitian ............................................................

1. 4

Tujuan Penelitian ................................................................

1. 5

Manfaat Penelitian ..............................................................

TINJAUAN PUSTAKA
2. 1

Penyakit Periodontal ...........................................................

2. 2

Gingiva ...............................................................................

2. 3

Sistem Penghantaran Obat Lokal ........................................

2. 4

Mukoadhesi .........................................................................

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2.4.1 Mekanisme Mukoadhesi .......................................

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2.4.2 Teori Mukoadhesi .................................................

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2. 5

Polimer Mukoadhesif ..........................................................

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2. 6

Metode Pembuatan Patch Mukoadhesif .............................

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2. 7

Natrium Diklofenak ............................................................

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2. 8

Sodium Carboxymethylcellulose .........................................

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2. 9

Hidroxypropilmethylcelullose..............................................

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2. 10 Poliuretan ............................................................................

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METODE PENELITIAN
3. 1

Alur Penelitian ....................................................................

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3. 2

Lokasi dan Waktu Penelitian ..............................................

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3. 3

Alat dan Bahan Penelitian ..................................................

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3. 3.1 Alat Penelitian .......................................................

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3. 3.2 Bahan Penelitian ...................................................

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Prosedur Kerja ....................................................................

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3. 4.1 Pembuatan Patch....................................................

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3. 4.2 Evaluasi Viskositas ................................................

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3. 4.3 Pembuatan Natrium Hidroksida (NaOH) 0,2 M ...

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3. 4.4 Pembuatan Kalium Dihidrogen Fosfat 0,2 M .......

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3. 4.5 Pembuatan Larutan Buffer Fosfat pH 6,8 ............

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Evaluasi Patch .....................................................................

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3.5.1 Organoleptis ..........................................................

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3.5.2 Keseragaman Bobot ..............................................

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3.5.3 Keseragaman Kandungan .....................................

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3.5.4 Keragaman Ketebalan ...........................................

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3.5.5 pH Permukaan ......................................................

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3.5.6 Uji Waktu Tinggal (In Vitro Residence Time).......

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3.5.7 Uji Pengembangan ................................................

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3.5.8 Pembuatan Kurva Kalibrasi ..................................

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3.5.9 Uji Kemampuan Penetrasi Zat Aktif .....................

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3.5.10 Uji Kebocoran Backing Membran ........................

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DAFTAR PUSTAKA ....................................................................................

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3. 4

3.5

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DAFTAR TABEL

Tabel 2.1 Perbandingan Kecocokan Daerah Mukosa Mulut untuk Penghantaran


Transmukosal ...............................................................................
Tabel 3.1. Formula Patch Natrium Diklofenak .............................................

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DAFTAR GAMBAR

Gambar 2.1

Gambaran diagramatik perubahan transisi gingiva sehat menjadi


penyakit periodontitis ..............................................................

Gambar 2.2

Tahapan proses pembentukan ikatan bioadhesif .....................

Gambar 2.3

Struktur kimia natrium diklofenak ..........................................

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Gambar 2.4

Struktur kimia sodium carboxymethylcellulose........................

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Gambar 2.5

Struktur kimia poliuretan ..........................................................

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Gambar 3.1

Diagram skematik franz diffusion cell untuk patch..................

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