Drugs that significantly inhibit P450 drug metabolism

CYP Family Inhibitor Drugs whose Metabolism Inhibited

1A2 Cimetidine Acetaminophen
Fluoroquinolones Clozapine
Grapefruit juice Haloperidol
Macrolides Theophylline
Isoniazid TCA
Zileuton Warfarin
2C9 Amiodarone Barbituates
Chloramphenicol Chloramphenicol
Cimetidine Doxorubicin
Isoniazid Ibuprofen
Metronidazole Phenytoin
SSRIs Chlorpromazine
Zafirlokast Steroids
Tolbutamide
S-Warfarin
2C19 Omeprazole Phenytoin
SSRI Topiramate
R-warfarin
2D6 Amiodarone Antidepressants
Cimetidine Flecainide
Quinidine Lidocaine
SSRI Mexiletine
Opiods
3A4 Amiodarone Antiarrhythmics
Azole antifungals Antidepressants
Cimetidine Azole antifungals
Clarithromycin Benzos
Cyclosporine Calcium channel blockers
Erythromycin Cyclosporine
Fluorquinolones Delavirdine
Grapefruit juice Doxorubicin
HIV Protease inhibitors Efavirenze
MEtronidazooole Erythromycin
Quinine Estrogens
SSRI HIV protease inhibitors
Tacrolimus Nafazodone
Paclitaxel
PPI
HMG CoA Red inhibitors
Rifabutin
Rifampin
Sildenafil
SSRI
Tamoxifen
Trazodone
Vinca Alkaloids
Drugs that induce P450 mediated drug metabolism

CYP Family Inducers Drugs whose Metabolism Induced

1A2 Benzopyrene Acetominophen
Carbamasepine Clozapine
Phenobarbitol Haloperidol
Rifampin Theophylline
Omeprazole TCA
Warfarin
2C9 Barbituates (phenobarbitol) Barbituates
Phenytoin Chloramphenicol
Primidone Doxorubicin
Rifampin Ibuprofen
Phenytoin
Chlorpromazine
Steroids
Tolbutamide
S-Warfarin
2C19 Carbamazepine TCA
Phenobarbitol Phenytoin
Phenytoin Topiramate
Warfarin
2E1 Ethanol Acetaminophen
Isoniazid Ethanol
Halothane
3A4 Barbs Antiarrhythmics
Carbamazepine Antidepressants
Corticosteroids Azole antifungals
Efavirenz Benzos
Phenytoin Calcium channel blockers
Rifampin Cyclosporine
Troglitazone Delavirdine
Doxorubicin
Efavirenze
Erythromycin
Estrogens
HIV protease inhibitors
Nafazodone
Paclitaxel
PPI
HMG CoA Red inhibitors
Rifabutin
Rifampin
Sildenafil
SSRI
Tamoxifen
Trazodone
Vinca Alkaloids