Gly-Lys : A

Gly-Glu-Lys : B

Glu Asp Lys Gly Ala

(CH2) 2-COOH CH2 -COOH (CH2) 4-NH2 CH3 R
B
A 2 1
 13 = PH 1 = PH
B 3-1

6 = Gly PHi
3 (

3 Ala-Asp-Ala-Gly-Glu-Asp

ASP
NH2 Gly
-
13 = PH 2-
PH 3-
PH 4-
 %20 %15

H H H
HOOC - CH2 - C - COOH , NH2 - (CH2 )4- C - COOH , H2N - C - COOH
NH2 NH2 CH2
Asp Lys Ala
1

2
105
HCL

(1 ) ((1) )

Hcl

HIS THR LEU ALa 1

H2N NH2

R1 H R2 R2
...
H2N - CH - C - CH - CO - - NH2 - CH - COOH ( 1) H2N NH2
O
R1 H
( 1)(H2N - CH - C - N - NH2 + ...) H2N - CH - COOH
O O
 2

1
2

2
OH CH3
R = - CH2 THR R = - CH Leu R = - CH2 - CH (Ala) R = - CH3
N NH CH3 CH3
CH

pH 3

pH
pH

1 pH

Ala = 6,02 THR = 5,65

His = 7,58
Leu = 5,98 2

(LTC) T 1

3
 T
1

1
2

LTC 2

LTC
ARN m
ARN m
ADN

Gly - Arg
Gly - Glu
Gly - Glu - Arg

H = GLY , (CH2)2 COOH = GLU R

NH
NH2 - C - NH - (CH2)3 = Arg

1 = PH
13 = PH
 CMH

NH2 CH2 CO NH CH CO NH CH COOH

=B
(CH2)2 (CH2)

COOH NH2

PH =1

PH = 13

PHi = 6 = gly

Gly
6 PH
[ gly ]
Gly -
Lys -
PH = 6
+ -
Gly Gly Lys
PHi = PH=6

Ala-Asp A a-Gly Gly-Asp

PH =
A a-Asp-Coo- COOH
Coo-
Ala-Asp
 A a - Gly - COO- COOH Ala -Gly
1
Glu - Asp - COO- COOH 3 Glu -Asp
COO- COO-
3
PH=13 PH
.4

PH=13
A a-Gly A a-Asp Glu-Asp
-1 -2 -3

PH=

Ala-Gly
A a-Asp Gly-Asp
-2 -3

PH=6 PHi Gly A a

 1

-
Ala
Asp
Lys

HCl 1 2

His Ala
1

His
Ala
2
Ala His
C
H2N - CH - C - NH - CH - COOH + H2O
CH CH2

Ph Ala Phi
 PH is Phi

is
Ala
PH

7,5 PH ,

1
1
LT

LT 2

3
LT

LTC

LTC

CMH LTC
CD8

(LTC + A9)
 2

2
H 2 2

2 2

OH

2
N 2

N
NH2 - C - NH - (CH2)3 - C - COOH
2

NH2 - C - CO - NH - C - CO - NH - C - COOH
(CH2)
NH2 - C - NH - (CH2)3
OH
/