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DAFTAR ISI

DAFTAR ISI.........................................................................................

BAB I

PENDAHULUAN .................................................................

BAB II TINJAUAN PUSTAKA......................................................


2.1

Tumbuhan Sekunyit (Fibraurea tinctoria Lour.)...............


2.1.1

4
4

Klasifikasi Tumbuhan Sekunyit (Fibraurea tinctoria Lour.)

............................................................................................4
2.1.2

Nama Daerah Sekunyit (Fibraurea tinctoria Lour.)

............................................................................................4
2.1.3

Morfologi Sekunyit (Fibraurea tinctoria Lour.)....

2.1.4

Manfaat Sekunyit (Fibraurea tinctoria Lour.).......

2.1.5

Kandungan Kimia Sekunyit (Fibraurea tinctoria Lour.)


................................................................................5

2.1.6 Habitat Tumbuhan Sekunyit (Fibraurea tinctoria Lour.)


............................................................................................6
2.2 Pankreas dan Pengaturan Glukosa Darah............................
2.2.1

2.3

2.4

Pankreas.................................................................

2.2.2 Glukosa Darah.........................................................

2.2.3 Insulin......................................................................

2.2.3.1

Kimia, Biosintesis, dan Sekresi...............

2.2.3.2

Peranan Insulin Terhadap Glukosa Darah

2.2.3.3

Efek Metabolit Insulin.............................

10

2.2.4 Glukagon...................................................................

11

Diabetes Mellitus................................................................

11

2.3.1

Sejarah....................................................................

11

2.3.2 Defenisi...................................................................

13

2.3.3 Etiologi....................................................................

13

2.3.4 Klasifikasi Diabetes Mellitus..................................

15

Gejala dan Komplikasi Diabetes Mellitus..........................

16

2.4.1

16

Gejala Diabetes Mellitus........................................

2.4.2 Komplikasi Diabetes Mellitus.................................

17

2.4.2.1

Bersifat Mendadak (Akut).......................

17

2.4.2.2

Bersifat Menahun (Kronis)......................

18

2.5

Metoda Penentuan Kadar Glukosa Darah..........................

22

2.6

Induksi Diabetes Mellitus...................................................

23

2.7

Ekstraksi.............................................................................

24

2.7.1

Defenisi Ekstraksi dan Ekstrak..............................

24

2.7.2

Proses Maserasi......................................................

25

2.7.3

Proses Pemekatan...................................................

26

BAB III PELAKSANAAN PENELITIAN


3.1

Tempat dan Waktu Pelaksanaan Penelitian.......................

28

3.2

Metodologi Penelitian .......................................................

28

3.2.1. Alat dan Bahan.......................................................

28

3.2.1.1

Alat..........................................................

28

3.2.1.2

Bahan.......................................................

28

3.2.2

Hewan Percobaan...................................................

28

3.2.3

Rancangan Penelitian.............................................

29

3.2.4

Prosedur Kerja........................................................

29

3.2.4.1

Pengambilan Sampel dan Identifikasi Sampel

Sekunyit..................................................................

29

3.2.4.2

Ekstraksi Sampel.....................................

29

3.2.4.3

Persiapan Hewan Percobaan...................

30

3.2.4.4

Perencanaan Dosis...................................

30

3.2.4.5

Penginduksian Diabetes..........................

31

3.2.4.6

Pembuatan dan Pemberian Sediaan Uji. .

31

3.2.4.7

Penentuan Kadar Gula Darah Hewan


Percobaan................................................

32

3.2.4.8

Pengukuran Berat Badan.........................

33

3.2.4.9

Pengukuran Volume Makan Mencit


Diabetes...................................................

33

3.2.4.10 Pengukuran Volume Air Minum Mencit


Diabetes...................................................

ii

33

3.2.4.11 Pengukuran Volume Urine Mencit.........

34

3.2.4.12 Penentuan Berat Relatif Organ Jantung,


Hati dan Ginjal Mencit Diabetes.............

34

3.2.4.13 Analisis Data............................................

35

DAFTAR PUSTAKA........................................................

36

LAMPIRAN.......................................................................

40

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DAFTAR GAMBAR

Gambar
1.

Halaman

Struktur
Aloksan
..............................................................................................................
28

2.

Skema Kerja Ekstraksi Akar dan Batang Sekunyit (Fibraurea


tinctoria
Lour.)
..............................................................................................................
40

3.

Skema Uji Aktivitas Antidiabetes Ekstrak Etanol Akar dan Batang


Sekunyit
(Fibraurea
tinctoria
Lour.)
..............................................................................................................
41

4a. Tumbuhan Akar Sekunyit (Fibraurea tinctoria Lour.)


..............................................................................................................
42
4b. Akar dan Batang Sekunyit (Fibraurea tinctoria Lour.)
..............................................................................................................
42

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