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MECHANISM OF DISEASE

4. Mapping
a. Mapping Konsep

IMUN
INFEKSI

FAKTOR

INTERAKSI
(SIMBIOSIS)

KLASIFIKASI

tempat
kejadian

jenis
patogen

mutualisme

jumlah
patogen

komensalisme

sporadic

opportunisme

endemic

keparahan

acute

local
infection
primary
infection

chronic
parasitisme

kemp.
destruksi

epidemic
pandemic

chronic with
acute
exarbation

secondary
infection
sub clinical
infection

latent
sistemic
infection

MODUL MAHASISWA

kemunculan

encounter

colonication

penetration

spread

damage
intracellular

sub acute

produksi
toksin

luas area

LOKASI
PATOGEN

STAGE

emerging

bulk
effect

extracellular

toxin
mediated

di luar tubuh

re-emerging

altered function of
host systems

host response to
infection

MECHANISM OF DISEASE

INFLAMASI
TUJUAN

PENYEBAB

repair

luka
bakar

rubor

iritasi
kimia

kalor

mencegah
kerusakan
lebih lanjut

TANDA-TANDA

tumor
toxic
dolor
infeksi
fungsiolesa

JENIS
inflamasi
akut
inflamasi
kronis

HIPERSENSITIVITAS
MEDIATOR
berasal dari
sel

MEKANISME

berasal dari
plasma

REAKSI
TIPE I

histamin

bradikinin

serangga

leukotrine

plasmin

serbuk sari

IFN -

thrombin

TNF -

complement

IL

faktor XII

jamur

membran
attack
complex

obat

prostaglandin
NO

alergen
hewan

makanan

MODUL MAHASISWA

REAKSI
TIPE II
perbedaan
rhesus ayah
dan ibu

REAKSI
TIPE III

REAKSI
TIPE IV
Merupakan
penyebab
utama
penolakan
yang terjadi
pada
transplantasi
organ

MECHANISM OF DISEASE

INUMODEFISIENSI

IMUNOTOLERAN
PEMBAGIAN
SEL
LIMFOSIT T

central
(timus)

SEL
LIMFOSIT B

perifer

central
(bone marrow)

Kongenital
Defek Sistem
Imun Innate

Defek Sistem
Imun Adaptive

perifer

PENYEBAB
Defek maturasi
limfosit

Acquired

Faktor
Proses penuaan

Complement

Limfosit B

Fagosit

Limfosit T

Malnutrisi
negative
selection

anergy

apoptosis

anergi

Severe
Combined
regulatory t
cell

supresi t
regulator

delesi

reseptor
editing

apoptosis

Mikroba
imunosupresif
Obat
imunosupresif
Obat
sitotoksik/radiasi
Tumor
Trauma
Penyakit lain
(diabetes)

MODUL MAHASISWA

Defek mekanisme
efektor pada
imunitas innate
maupun adaptive
Defek sel T
regulator (yang
bertugas mengatur
sel toleran)

EFEK
Defisiensi pada
imunitas
humoral
Defisiensi pada
imunitas seluler
Defisiensi
humoral =
seluler

MECHANISM OF DISEASE
b.

Mapping Kasus

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MODUL MAHASISWA