Precipitating factors : Obesity Presence of trophoblastic disease

Etiology : Hormonal Changes in Pregnancy

Predisposing Factors : Race Heredity Multiparity

hCG level

Excessive hCG stimulates secretion of electrolytes

Distending and activating GIT Mechanoreceptors

Emesis Gravidarum

Thyroid Stimulating Hormone receptor Transient Hyperthyroidism of Hyperemesis Gravidarum

Hyperemesis Gravidarum

Severe Nausea and Vomiting

Metabolic Alkalosis

Dehydration

a.) Rise of plasma HCO3b.) Causes a shift of potassium from the plasma and interstitial fluids into cells

Electrolyte Imbalance (Hypokalemia)