Anda di halaman 1dari 2

Patogenesis inflamasi dan dekstruksi jaringan pada psoriasis arthritis

CD8 T cell Target join tissue cognitive recognition CD8 T-cell activation & clonal expansion IFN- Angiogenesis recruitment Macrofag activation TNF- Periostenal new bone formation Kapilerisasi Dilatasi TNF- CD4 & CD8 Tcell

Mesenchymal proliferation & alteration in gene expansion

inflamasi, deksruksi, fibrosis

Stages
HLA-genes genes unknown

Tcell receptor sesceptibility Tolerance broken response Auto antigen drive initiated trauma; infection psoriasis triggers ; inflammation T-cell

Enlarged of autoreactive T-cels in blood and skin Transition of autoimmmune response to joint Cytokine release Erosions, fibrosis

Psoriatic arthritis

Anda mungkin juga menyukai