CD8 T cell Target join tissue cognitive recognition CD8 T-cell activation & clonal expansion IFN- Angiogenesis recruitment Macrofag activation TNF- Periostenal new bone formation Kapilerisasi Dilatasi TNF- CD4 & CD8 Tcell
Stages
HLA-genes genes unknown
Tcell receptor sesceptibility Tolerance broken response Auto antigen drive initiated trauma; infection psoriasis triggers ; inflammation T-cell
Enlarged of autoreactive T-cels in blood and skin Transition of autoimmmune response to joint Cytokine release Erosions, fibrosis
Psoriatic arthritis