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ACUTE INFLAMATION

BAGIAN PATOLOGI ANATOMI FK - UMI

INFLAMATION

DYNAMIC PROSSES LIVING TISSUE REACT INJURY.

ACUTE INFLAMATION

GROSS : - REDNESS ( RUBOR ) - HEAT ( CALOR ) - SWELLING ( TUMOR ) - PAIN ( DOLOR ) - LOSS OF FUNCT. (FUNCTIO LAESA)

ACUTE INFLAMATION

MICROS : - HYPERAEMIA - EXUDATION - EMIGRATION OF LEUCOCYTES

HYPERAEMIA

MICRO-VASCULAR CHANGES LEWISS TRIPLE RESPONSE : - FLUSH, - FLARE, - WEAL STROKE WHITE LINE (VS.CONTR) FLUSH DULL RED LINE (CAP.DIL) FLARE BRIGHT RED (ART.DIL)

EXUDATION

PROT FLUID INTERSTIAL - WEAL FLUID INCR. DILUTION OF TOXIN PROTEIN INCR : - GLOBULIN ANTIBODIES - FIBRIN TO LIMIT SPREAD (BACT) WOUND HEALING

EXUDION (MECHANISM)

PROTEIN PASSAGE : - CHEM.MED. ENDLIAL DAMAGE INC.PERMEABILITAS

EXUDION (MECHANISM)

FLUID MOVEMENT : - HYPERAEMIA CAP. B.P. INCR. INCR.FILTR.PRESSURE. -LOSS OF PROTEIN (CAP) DECR.PLM.OSMOTIC PRSS INCR.FILTR.PRSS. -TISSUE PROTEIN INCR. INCR.TISS.OSM.PRSS. INCR.FILTR.PRSS. -INCR.FILTR.PRSS. OEDEMAINCR. LYMPH FLOW FROM AREA.

EMIGRATION OF LEUCO.
PMN & MN PASS (AMOEBOID) NORMAL AXIAL STREAM(VENULE) ACUTE INFL: EXUD.FLD INCR.VISC. SLOWING FLW AXIAL STR (-) MARGINATION (PMN) EMIGR/PMN & DIAPEDESIS OF RED CELLS.

ACUTE INFLAMATION

PHAGOCYTOSIS : - PMN/MACROPHAGE INGEST (DEB BRIS AND FOREIGN PARTICLE). INFLUENCE FCT : - OPSONIN - COMPLEMENT - PHYSIC OF CELL.ENVIRONMENT.

SQ OF ACUTE INFLAMATION
ACUTE INFL : RESOLUTION SUPURATION ( discharge of pus) REPAIR & ORGANIZATION fibrosis CHRONIC INFL

RESOLUTION

TO NORMAL CONDITION. POTENTIAL CONDITION : * MINIMAL LESION * RAPID ELIMINATION * LOCAL CONDITION EXAMPLE RESOLUTION OF LOBAR PNEOMONIA.

SUPPURATION

FORMATION PUS ABSCESS PYOGENIC INFECTION : COCCI COMPOSITION : - SUPERNATAN PROTEIN FLUID - DEPOSIT PMN, BACTERIA, FRAG MENTS CELL

EVOLUTION ABSCESS

TISSUE DAMAGE (BACTERIA) INFLAMATION (EDEMA, HYPEREMIA) BACT. MULTIPLY, PMN (CENTRAL) PUS (+) EPID. (THIN) RUPTURE CAV.COLLAP ORG & FIBROSIS FINAL SMALL SCAR.

EVOLUTION ABSCESS

DEEP ABSCESS : SINUS (CHR.INFC) LOCALISED PUS : - SMALL ABSORB. SCAR - LARGE COLLECTED SUROUND (FIBROUS) CALCIUM SALT.

INFLAMATION CELLS

NEUTROPHIL / POLYMORPHONUCL LEUCOCYTE (PMN) LYMPHOCYTE EOSINOPHILS MONOCYTE MAST CELLS (BASOPHILS)

POLYMORPHONUCLEAR

FROM BONE MARROW LIFE SPAN 2 3 DAYS FUNCTION : - PHAGOCYTOSIS - KILLING MO NORMAL COUNT : 3.000 7.500/MM3 INFECTION > 10.000/MM3

LYMPHOCYTES
FROM LYMPHOID NODE PROD. ANTIBODIES & CELLULAR COMPONENT IMMUN RESPONSE COUNT : 1,500 3.500 / MM3 VIRAL INFECT. & CHRONIC BACT.INF LYMPHOSITOSIS B. LYMPHOCYTE PLASMA CELLS Ig

EOSINIPHILS

DERIVED FROM BONE MARROW NORMAL 1 4 % EOSINOPHILIA : - HELMINT INFECT. - PARASITES - ALLERGIC ASTHMA

MONOCYTES

TOTAL WHITE CELLS : 4 7 % AS MACROPHAGE, LOCAL INFLAMATION REACTION NCREASED :-CHR.BACT.INFECT(TB) - PROTOZOAL(MALARIA) EPITHELOID CELLS MACROPHGE FUSION GIANT CELLS

MAST CELLS

BASOPHILS < 1 % SCATTERED CONN.TISSUE DERIVED FROM BONE MARROW CONTAIN : - HISTAMINE - HEPARINE - ENZYMES REALEASED BY CHEMICAL FACTOR (INFLAMATORY REACTION)

INFECTION MECHANISM

TOXIN PRODUCTION : (EXO/ENDO) HYPERSENSITIVITY REACTION BLOOD STREAM : - BACTERAEMIA - SEPTICAEMIA - PYEMIA

BACTERIAL INFECTION
LOCAL INFL NON LC INF

BLOOD STREAM
BACTERIE MIA SEPTICAE MIA PYAEMIA

BACTERAEMIA

COMMONLY NO SERIOUS INTEGRAL PART OF SOME INFECTION TYPHOID FEVER DENTAL EXTRACTION BACTERAEMIA B.ENDOCARDITIS / SEPTICAEMIA

SEPTICAEMIA

VERY SERIOUS CONDITION TOXAEMIA AND SHOCK FORM : - PRIMARY - COMPLICATE - IMMUNE DECREASED

PYAEMIA

SEVERE CONDITION (+ TOXAEMIA) SMALL AGGREGATE MICR.EMBLM FORM : - PYAEMIC ABSCESSES - SEPTIC INFARCTION

PYAEMIC ABSCESS

SEPTIC FOCUS ( STAPH ) THROMBOSIS OF VENULES MICROEMBOLI MULTIPLE ABSCESS (VARIOUS ORGANS) - CEREBRAL CORTEX, MYOCARDIUM, LUNGS, RENAL CORTEX.

SEPTIC INFARCTION

LARGE SEPTIC THROMBOSIS - SUPP.VEIN THROMBOPHLEBITIS EMBOLISM INFARCTTION + SUP PURATION LUNG & LIVER. - ACUTE BACT.ENDOCARDITIS VE GETATION MITRAL VALVE VIA AR TERIAL BRAIN, KIDNEYS & SPLEEN

PYOGENIC BACTERIA

STAPH.A.(PHARYNX, NOSE, PERINEAL) COAGULASE + FIBRINE ABSCESS - SKIN PUS, BOILS, CARBUNCLE - WOUND STAPH.PNEUMONIA - BLOOD STREAM PYAEMIA

PYOGENIC BACTERIA

STREPT.PYOGENES PHARYNX HYALURONIDASE, STREPTOKINASE, LEUCOCIDIN. - SKIN IMPETIGO, ERISIPELAS, CEL LULITIS, LYMPHANGITIS. - WOUND TONSILITIS, PHARYNGITIS

PYOGENIC BACTERIA

MENINGOCOCCUS NASOPHARYNX PURULENT MENINGITIS (CHILD) FATAL SEPTICAEMIA. SKIN RASH & MASSIVE ADRENAL HEMORRHAGE (WATERHOUSE FREDERICHSEN SYNDROME)

PYOGENIC BACTERIA

GONOCOCCUS ( GENITAL M.MEMBR) PURULENT (URETHRA & CERVIX) ANT.URETHRITIS, PROSTATITIS, EPIDIDYMITIS (MALE) CERVICITIS, ACUTE SALPINGITIS ( FEMALE) STERIL

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