SANS-(T1 thoracic L2 lumbar) ShortPreganglion, longpostganglion

Neruotransmitters(Catecholamines):

Isoproterenol(exogenous )=b Receptors; a adrenergic - Vasoconstrictorsexcitatory-Bld vessels (glycogenformation) b1 & b2 adrenegic - Vasodilators-inhibitory Heart Lungs

Adrenergic, Sympathomimetic,

AdrenergicBlockers,sympatholytic

Cardiac- Epi has both a & b systolicdiastolic NE mostly a =both pressures Isoproterenol= mostly b diastolic Hint: a = high pressure, constriction b = low pressure, vasodilation Eye= Treat Glaucoma due to a Treat Mydriasis due to b

they do the opposite

CNS = Excitement, alertness Direct- Epi ,NE, Isoproterenol Indirect-Amphetamines release NE= response Mixed-i.e ephedrinestimulate receptor to release NE= response SalivaryGlands=Submaxillary & sublingual saliva Salivary- saliva

Specific AdrenergicDrugsUses

AdrenergicBlockersUses

Vasoconstrictorsin anesthesia Hemostasis Decongestant Epi treat shock, acute asthma, anaphylaxis. phenylephrine(Neo-Synephrine)-Midryasis,fame for nasal decongestant. Levonordefrin(BeiCobefrin)- Vasoconstrictor in LA, less CNS stimulation, derivative of NE dopamine(Intropin)-treat shock, A & B agonists dipifevrin(Propine)- treat glaucoma ephedrine&pseudoephedrine(Sudafed)methamphatamine AmphetaminesDiet Ritalin, Dexedrine- treat ADD in kids and adults.

1.BetaBlockers : blockBetareceptors (olol) ProduceBronchoconstriction,Bradycardia atenolol(Tenormin)-acts more on heart, bld vessels than lungs. Propranolol(Inderal)hypertension, prophylaxis migraines, arrhythmias, angina.

2.A AdrenegicBlockers
BP, PR, vagal reflex, tachycardialreflex.

3.A & B blockers end in alol

labetalol(Normodyne,Trandate)-hypertension without reflex tachycardia.

A & B actions
a receptors Vasoconstrict b receptors Vasodilate BP BP PR(peripheral resist.) PR vagal reflex vagal reflex tachycardial reflex tachycardial reflex