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Achilles tendon rupture

This 81-year-old woman presented with swelling and pain in the left foot a week after treatment for acute bronchitis.

Question This 81-year-old woman presented with swelling and pain in the left foot a week after treatment for acute bronchitis. Which one of the following treatments is most likely to have been contributory? A. Beta-adrenergic agonist B. Cephalosporin antibiotic C. Leukotriene receptor antagonist D. Guaifenesin expectorant E. Fluoroquinolone antibiotic Explanation : The magnetic resonance image of the ankle reveals a near-full-thickness rupture of the Achilles tendon. Treatment with fluoroquinolone antibiotics has been associated with an increased risk of Achilles tendon rupture. Quinolones may facilitate the enhanced expression of matrix metalloproteinases in tissue, which in turn causes tendon injury. The other listed choices have not been consistently linked with an increased risk of tendinopathy.

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