V.

PATHOPHYSIOLOGY

Post-streptococcal infection
(group-A, beta hemolytic)

Release of material from the organism,

into the circulation (antigen)

Formation of antibody

Immune complex reaction in the

glomerular capillary

Inflammatory response

Proliferation of epithelial cells lining

glomerolus & cells between
endothelium & epithelium of capillary
membrane

Swelling capillary membrane &

infiltration with leukocytes

↑ Permeability of base membrane

 Occlusion of the capillaries of the
glomeruli vasospasm of afferent
ventrioles

↓ Glomerular filtration rate

↓ Ability to form filtrate from

glomeeruli plasma flow

Retention of H2O & Na; hypovolemia;

circulatory congestion

Edema
Hypertension
↓ urinary output
Urine dark in color
Anorexia
Irritability lethargy

ACUTE
GLOMERULO-
NEPHRITIS