Panhypopituitarism o Reduction in all anterior pituitary o Congenital defect or acquired o Cause in adults Caniopharyngiomas Chromophobe tumors Thrombosis of pituitar

tar o Clinical symptoms Hypothyroidism Sexual dysfunction Decreased glucocorticoid production GH Defenciency O In childhood Dwarfism - decreased anterior pituitary hormones 'A have defects in only GH secretion Normal proportions, abnormal growth rate Delayed puberty, short stature, overweight Causes: ,GHRH no IGF production GH receptor deficiency Excess GH Pre-puberty: Gigantism Causes: hypersecretion from acidophilic cells of pituatary tumor(major) Prior to epiphyseal fusion with long bone shaft Heights up to 8 ft Hyperglycemia 10% type II diabetes Panhypopituitism eventually develops because in many cases, gigantism is caused by a posterior pituatry tumor 0 Postpuberty: Acromegaly Causes: hypersecretion from acidophilic cells or pituitary tumor(major) Occurence: adults Enlargement of hand, feet, facial, and cranial bones Lower jaw and forehead protruision Large nose Kyphosis Enlargement of liver, kidneys. spleen Glucose intolerance S ndrome of Ina ro riate ADH secretion SIADH ADH hyponatremia Causes: ADH secreting tumors pulmonary diseases drugs: nicotine, NSAIDs, some psychotropic meds Diabetes Insipidus

Diseases