Toxidromes

Toxidrome Sympathomimetic Examples Cocaine Methamphetamine Clinical Features Agitation Diaphoresis Hypertension Hyperthermia Dilated pupils Tachycardia Depressed mental status Hypoventilation Constricted pupils Muscarinic !! Nicotinic !!! Central
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Antidote(s) Benzodiazepines

Opioid

Cholinergic (Anticholinesterase) Sedative-Hypnotic

Heroin Hydromorphone Methadone Morphine Oxycodone Pesticides (Carbamates Organophosphates) Nerve agents Barbiturates Benzodiazepines GHB Beta-blockers Calcium Channel Blockers Atropine Jimson Weed Scopolamine Diphenhydramine Tricyclic Antidepressants Antiarrhythmics Type 1A agents (quinidine, procainamide) Type 1C agents (flecainide, propofenone)
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Naloxone

Atropine Pralidoxime Supportive Therapy (No antidote) Glucagon Calcium chloride Physostigmine (ED)

Cardiotoxic drugs

Anticholinergic

Sodium Channel Blockers

Depressed mental status Hypotension Hypothermia Bradycardia Cardiac conduction issues Hypotension Delirium Hyperthermia Tachycardia Warm, dry skin Altered mental status Hypotension Seizures Wide-Complex Tachycardia

Sodium Bicarbonate

Muscarinic: Diarrhea Urination Miosis Bradycardia, Bronchospasm, Bronchorrhea Emesis Lacrimation Salivation, Secretions, Sweating

Nicotinic: Mydriasis Tachycardia Weakness Hypertension, Hyperglycemia Fasciculations

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Central: Confusion Convulsions Coma