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SITE OF ACTION OF DRUGS ACTING ON ADRENERGIC NEUROHUMORAL TRANSMISSION

Na+ LiverPhenyal alanine tyrosine K+


STIMULATION INHIBITION

TYROSINE

ADRENERGIC NERVE TERMINAL

1.ALPHA METHYL P-TYROSINE


tyrosine hydroxylase

DOPA
DOPA decarboxylase

2.ALPHA METHYL DOPA CARBIDOPA

DOPAMNE
SYNAPTIC VESICLE

3.ALPHA METHYL DOPAMINE DOPAMNE


Beta dopamine hydroxylase

6.RESERPINE
Inactive metabolites

MAO
Vesicula r uptake

NOREPINEPHRINE [Type a quote from the document or (BOUND) the summary of an interesting point. You can position the text box NOREPINEPHRINE anywhere (FREE) in the document. Use the Text Box Tools tab to change the formatting of the pull quote text box.]

Action PotentialCa2+

7.MAO INHIBITORS NE NE
EXOCYTOSIS

4.TYRAMINE LIKE DRUGS: EPHEDRINE, TYRAMINE,AMPHETAMINE

5.BRETYLIUM, GUANETHEDINE

8.UPTAKE I INHIBITORS UPTAKE I 9. UPTAKE II INHIBITORS


alpha 2 receptor

10. ALPHA 2 AGONISTS


NOR EPINEPHRINE COMT INHIBITORS

COMT

Inactive metabolites

UPTAKE II

11.ALPHA AGONISTS 12.BETA AGONISTS

13. ALPHA BLOCKERS

14.BETA BLOCKERS

alpha 1 and 2 receptor

EFFECTOR ORGAN RESPONSE/ EFFECT

Beta receptor