PROGNOSIS WORKSHEET Citation:

Are the results of this prognosis stud !alid" Was a defined, representative sample of patients assembled at a common (usually early) point in the course of their disease? Was patient follow-up sufficiently long and complete? Were objective outcome criteria applied in a blind fashion? f subgroups with different prognoses are identified, was there adjustment for important prognostic factors? Was there validation in an independent group (test set) of patients?

Are the !alid results of this prognosis stud i#portant" !ow li"ely are the outcomes over time? !ow precise are the prognostic estimates?

If ou $ant to %al%ulate a %onfiden%e inter!al around the #easure of prognosis: Clini%al &easure Standard Error 'SE( T pi%al Cal%ulation of CI #roportion (as in the rate f p & *+(,- & -$+ (or +-.) of some and n & ,prognostic event, { p () p ) ( n} /0 & {-$+ () -$+) ( ,-} etc$) where% & -$-,1 (or ,$1.) where p is proportion the number of patients & n and n is number of 23. 4 is +-. 5 )$2, 6 ,$1. patients the proportion of these patients or *7$,. to 3*$+. who e'perience the event & p n from your evidence% 888 p from your evidence% 888 9our calculation% /0% 888888888888 23. 4 % 88888888

Can ou appl this !alid) i#portant e!iden%e a*out prognosis in %aring for our patient" Were the study patients similar to your own? Will this evidence ma"e a clinically important impact on your conclusions about what to offer or tell your patient? Additional notes: