And the most soluble? Nitrogenous Wastes Contain nitrogen Breakdown product of proteins, nucleic acids Toxic The Solubility and Toxicity of Nitrogenous Wastes Ammonia: most toxic; most soluble Urea: less toxic; less soluble Uric acid: least toxic; least soluble Bioenergetics of Nitrogenous Wastes Ammonia: smallest, cheap to produce Urea: larger requires ATP to produce Uric acid: largest most expensive to produce