LEFT VENTRICULAR HYPERTROPHY

Hypertrophy of heart is defined as increase in size !ei"ht of the #yocardi$#% It "enera&&y res$&ts fro# increase press$re &oad !hi&e increase 'o&$#e &oad in hypertrophy !ith dia&atation of the affected cha#(er d$e to re"$r"itation of the (&ood thro$"h inco#petent 'a&'es

It appears that strechin" of #yocardia& fi(res in response to stress ind$ces the ce&&s to increase in &en"th Others sti#$&atin" factors are ano)ia *inf&$ence of certain hor#ones + CA s * Pit$itatry "ro!th hor#one

Ca$ses of LVH

,yste#ic hypertension Aortic stenosis and ins$fficiency -itra& ins$fficiency Coarctation of the aorta Occ&$si'e coronary artery disease Con"enita& ano#a&ies &i.e septa& defects and patent d$ct$s arteriosis Conditions !ith increased cardiac o$tp$t e%"% thyroto)icosis*anae#ia*arterio'eno$s fist$&ae

Patho&o"ica& Chan"es

Concentric Hypertrophy / hypertrophy of the #yocardi$# !itho$t di&atation% Eccentric hypertrophy / hypertrophy of the #yocardi$# !ith di&atation%

0ross Findin"s

In concentric hypertrophy / &$#en of LV cha#(er is s#a&&er than $s$a&% In eccentric hypertrophy / the &$#en of LV cha#(er is di&ated% In p$re hypertrophy / the papi&&ary #$sc&es tra(ec$&ater carneae are ro$nded en&ar"ed%

-icroscopic Findin"s

Increase in size of indi'id$a& #$sc&e fi(res% -$&tip&e #in$te foci of de"enerati'e chan"es necrosis in hypertrophied #yocardi$#% Chan"es arises as a res$&t of re&ati'e hypo)ia of hypertrophied #$sc&e as the (&ood s$pp&y is inade1$ate%

THAN2 YOU