Apoptosis Pathway

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Kinase Phosphatase Ligand Transcription Factor Other Receptor Phospho
Activation
Membrane Cell Function Binding/
Association
Activation Inhibition Indirect Effect Dissociation
Denotes a Bioss publication
P
Cell Membrane
Survival
cIAP
Calpain cAMP
PKA
Bad
NGF
IL-3
FASL
TNF
IL-1
MyD88 IRAK
FADD
Caspase2
DAPK
RIP
TRAF2
PI3K
Akt
Bax
Caspase12
Caspase3
NIK
IKK
IkB
NFB
Survival
Genes
Bcl-xl
Survival
IAP
Bcl-2
Caspase6
Cleavage of
Caspase
substrate
DNA Fragmentation
Degradation Apoptosis
DNA Repair
Apoptosis
DNA Damage
Death Genes
Stress Signals
Intrinsic Pathway
Degradation
IL1-R
TNF-R1
FAS
TrkA
IL-3R
Ca
2+
Rises
ER Stress
RelA
Daxx
FADD
RAIDD
TRADD
FADD
ASK
PTEN
JNK
Bcl-2 Caspase8
Bim
Mcl-1
Caspase10
Caspase3
CytC
Apaf-1
AIF
Caspase9
DFF45
IAP
PARP
ATM
p53 Bcl-2
DFF45
BAK
FHIT
MOAP-I
RASSF1A
DFF40
Bid
DFF40
Caspase7
ENDO-G
TRADD