ALMINSYAH K1A110025 ABSTRACT Ipomoea pes caprae ( L ) R. Br contains terpenoids , saponins , alkaloids , tannins and flavonoids are commonly used by the people of Indonesia to treat wounds , ulcers and is also an antioxidant . The purpose of this study is to determine how much inhibition hoof leaf extract can inhibit Staphylococcus aureus isolated from patients infected wounds at a concentration of 100 % , 50 % , 25 % , 12.5 % , 6.25 % , 3.125 % and 1.56 % This research was conducted with post-test design with a control only independent variable in the form of leaf chloroform extract hoof and erythromycin ( as control ) against Staphylococcus aureus . Results of evaporation is taken as much as 10 grams and dissolved in 10 ml of chloroform . This test uses paper disc diffusion method on Mueller Hilton planted order that has been mixed bacterial test and then diikubasikan observed inhibitory zone diameter The results obtained showed that the konsntrasi 100% inhibitory zone was 12 mm , 50 % at 10 mm , 25 % by 9 mm , 12.5 % at 8 mm by 8 mm 6.25 % , 3.125 % at 5 mm and 1 , 56 % of 0.6 mm . Conclusion on the study were chloroform extract of leaves hooves have inhibitory response to the growth of Staphylococcus aureus bacteria . Keywords : Ipomoea pes caprae ( L ) R. Br , test inhibition , Erythromycin , Staphylococcus aureus