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  • Agonist Mechanism Agonists Antagonists: Adrenore Ceptor Agonist Potency Order Selected Action of

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    dw
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    This document summarizes the different adrenoreceptor subtypes (α1, α2, β1, β2, β3), their agonist potency order, main actions, and signaling mechanisms. For each subtype it lists examples of agonists that activate the receptor and antagonists that block the receptor.

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    Adrenergic Adrenoreceptors

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    This document summarizes the different adrenoreceptor subtypes (α1, α2, β1, β2, β3), their agonist potency order, main actions, and signaling mechanisms. For each subtype it lists examples of agonists that activate the receptor and antagonists that block the receptor.

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    © All Rights Reserved
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    17 tayangan1 halaman

    Agonist Mechanism Agonists Antagonists: Adrenore Ceptor Agonist Potency Order Selected Action of

    Diunggah oleh

    dw
    This document summarizes the different adrenoreceptor subtypes (α1, α2, β1, β2, β3), their agonist potency order, main actions, and signaling mechanisms. For each subtype it lists examples of agonists that activate the receptor and antagonists that block the receptor.

    Hak Cipta:

    © All Rights Reserved
    Unduh sebagai DOCX, PDF, TXT atau baca online dari Scribd
    Tandai sebagai konten tidak pantas
    dari 1

    1

    Adrenore
    ceptor
    Agonist potency order Selected action of agonist Mechanism Agonists Antagonists
    1:
    A, B, D


    Norepinephrine
    > epinephrine
    >> isoprenaline
    Smooth muscle contraction Gq: phospholipase C(PLC) activated, IP3,and DAG, rise in calcium
    (Alpha-1 agonists)
    Noradrenaline
    Phenylephrine
    Methoxamine
    Cirazoline
    Xylometazoline
    Midodrine
    (Alpha-1 blockers)
    Alfuzosin
    Doxazosin
    Phenoxybenzamine
    Phentolamine
    Prazosin
    Tamsulosin
    Terazosin
    (TCA:s)
    1. Amitriptyline
    2. Clomipramine
    3. Doxepin
    4. Trimipramine
    2:
    A, B, C
    Epinephrine

    norepinephrine

    >> isoprenaline
    Smooth muscle mixed effects and neurotransmitter
    inhibition & Cardiac
    muscle relaxation platelet activation
    Gi: adenylate cyclaseinactivated, cAMP down
    (Alpha-2 agonists)
    1. Dexmedetomidine
    2. Medetomidine
    3. Romifidine
    4. Clonidine
    5. Brimonidine
    6. Detomidine
    7. Lofexidine
    8. Xylazine
    9. Tizanidine
    10. Guanfacine
    11. Amitraz
    (Alpha-2 blockers)
    Phentolamine
    Yohimbine
    Idazoxan
    Atipamezole
    1
    Isoprenaline

    > epinephrine

    = norepinephrine
    Heart muscle contraction Gs: adenylate cyclaseactivated, cAMP up
    Dobutamine
    Isoprenaline
    Noradrenaline
    (Beta blockers)
    Metoprolol
    Atenolol
    2
    Isoprenaline

    > epinephrine

    >> norepinephrine
    Smooth muscle relaxation Gs: adenylate cyclaseactivated, cAMP up (alsoGi, see 2)
    (Short/long)
    1. Salbutamol(Albuterol in USA)
    2. Bitolterol mesylate
    3. Formoterol
    4. Isoprenaline
    5. Levalbuterol
    6. Metaproterenol
    7. Salmeterol
    8. Terbutaline
    9. Ritodrine
    (Beta blockers)
    Butoxamine
    Propranolol
    3
    Isoprenaline = norepinephrin
    e > epinephrine
    Enhance lipolysis, promotes relaxation of detrusor
    muscle in thebladder
    Gs: adenylate cyclaseactivated, cAMP up
    1. L-796568
    [2]

    2. Amibegron
    3. Solabegron
    SR 59230A

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