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OPP

OPP =
O P
O
O
O P
O
O
O
enzyme-H+
protonation
carbocation intermediate 1
cyclization
carbocation intermediate 2
OPP
OPP
H
H
carbocation intermediate 3
cyclization
OPP
addition of
H
2
O
protonated intermediate
OPP
proton
loss
OPP
OH
ionization
of -OPP
carbocation intermediate 4
resonance structure of 3
OH OH
S
N
1
reaction;
neutralize
known biological intermediate
O
HO
OH
O
OH
OCOCH
3
forskolin
The following reactions occur in the enzymatically controlled biosynthetic of forskolin. Forskolin is an active
component in traditional Indian medicine and has pronounced hypotensive and antispasmodic activity.
Using the supplied skeletons and the given directions, complete each of the following structures to be consistent with
the mechanistic sequence. This may require you to add pi bonds, positive charges, or other features.
further
biological
processing