DRUG SPECTRUMS

OF ANTIMICROBIALS


9/17/2010
AIMC/JHL LHR
SOHAIB


*Key to the spectrum pie charts
GRAM + COCCI
GRAM + BACILLI
GRAM - COCCI
GRAM - RODS
ANAEROBIC
SPIROCHETES
MYCOPLASMA
CHLAMYDIA
OTHER


PENICILLIN G

METHICILLIN, NAFICILLIN, ISOXAZOLYL PENICILLINS

GRAM + COCCI
Strept Pneumoniae
Strept Pyogenes
Strept Viridans
Enterococci
Staphylococci
GRAM + BACILLI
Bacillus Anthracis
Corynebacterium
Diphtheria
GRAM - COCCI
Neisseria Gonorrheae
Neisseria
Meningitidus
ANAEROBIC
Clostridium
perfingens
SPIROCHETES
Treponema pertenue
Treponema pallidum
OTHER
Actinomyces
GRAM + COCCI
Enterococci
MR Staphylococci
GRAM + BACILLI
Listeria
monocytogenes


AMPICILLIN (Aminopenicillins)

1
ST
GENERATION CEPHALOSPORINS

GRAM + COCCI
Enterococci
GRAM + BACILLI
Listeria
monocytogenes
GRAM - COCCI
B lactamase -ve
strains
GRAM - RODS
E coli
H influenzae
Proteus mirabilis
Salmonella typhi
GRAM + COCCI
Staph aureus
Staph epidermidis
Strept pneumoniae
Strept pyogenes
GRAM - RODS
E coli
Klebsiella
pneumoniae
Proteus mirabilis
ANAEROBIC COCCI
Peptococcus
Peptostreptococcus


2
nd
GENERATION CEPHALOSPORINS

3
rd
GENERATION CEPHALOSPORINS

GRAM + COCCI
Strepy pneumoniae
Strept pyogenes
GRAM - COCCI
Neissera gonorrheae
GRAM - RODS
Enterobac.
aerogenes
Escericia coli
H influenzae
B fragilis
Klebs pneumoniae
P mirabilis
ANAEROBIC
Streptococci
GRAM - COCCI
N gonorrheae
GRAM - RODS
Citrobacter
S marcescens
Providencia
P aeroginosa
B fragilis
Ent aerogenes
E coli
K pneumoniae
P mirabilis
H influenzeae


4
th
GENERATION CEPHALOSPORIN

MONOBACTAMS

GRAM + COCCI
Staph aureus
Strep pneumoniae
GRAM - COCCI
Neisseria
GRAM - RODS
P aeroginosa
Enterobactereciae
Hemophilus
GRAM - RODS
Only aerobic gram -
ve
rods including
pseudomonas


IMIPINEM

VANCOMYCIN

GRAM + COCCI
Staph aureus
Staph epidermidis
Enterococcus faecalis
Strept pneumoniae
Strept group A,B,C
GRAM + BACILLI
Listeria
monocytogenes
GRAM - COCCI
N gonorrheae
N meningitidis
GRAM - RODS
Acinetobacter sp
Citrobacter
Enterobacter sp
E coli
Gard. vaginalis
H influenzae
Klebsiella, Proteus
Providencia
P aerogenosa
Salmonella
Serratia
ANAEROBIC
Clostridium sp
Peptococcus sp
Peptostreptococcus
Propionobacterium
Bacteroides sp
Fusobacterium sp
OTHER
Actinomyces
Nocardia
GRAM + COCCI
Staph aureus (inc
MRSA)
Staph epidermidis
Streptoc group ABC
Strept pneumoniae
Enterococcus fecalis
Enterococcus fecium
GRAM + BACILLI
Listeria
monocytogenes
ANAEROBIC
Clostridium sp
OTHER
Actinomyces


TETRACYCLINES

TIGECYCLINE

GRAM + BACILLI
Bacillus anthracis
GRAM - RODS
Brucella sp
Vibrio cholera
Yersinia pestis
H pylori
ANAEROBIC
Clostridium
perfingens
Clostridium tetani
SPIROCHETES
Borrelia burgdoeferi
Leptospira
interrogans
MYCOPLASMA
Mycoplasma
pneumaniae
CHLAMYDIA
Chlamydia sp
OTHER
Rickettsia rickettsii
Balantidium coli
E histolytica
Pl falciparum
GRAM + COCCI
Staphylococci
MRSA, VISA, VRSA
Streptococci
Enterococci


GRAM + BACILLI
Gram +ve rods
GRAM - RODS
Enterobactericeae
Acinetobacter
Legionella
CHLAMYDIAE
Chlamydia sp
OTHER
Ricketsiae
Mycobacterium


MACROLIDES

KETOLIDES

GRAM + COCCI
Staph aureus
Strept pyogenes
Strep pneumone
GRAM + BACILLI
C. diphtheriae
L. monocytogenes
GRAM - COCCI
Moraxela catarhalis
N. gonorrheae
GRAM - RODS
Bordetela pertusis
Campylob. jejuni
H. influenzae
Legionela
pneumophila
H pylori
Bartonela henselea
B. quintana
SPIROCHETES
Treponema pallidum
MYCOPLASMA
Mycoplasma
pnumonia
Ureaplasma
urealytcum
Myc. legionella
CHLAMYDIA
C. pneumonia
C. psittaci
C. trachomaticus
OTHER
M. kansii
M. scrofulaceum
some Richetsiae
MAC (Clar)
M. leprea (Clar)
T. gondii (Clar)
GRAM + COCCI
S pyogenes
Spneumoniae
S aureus
GRAM - COCCI
Moraxella catarhalis
N gonorrheae
GRAM - RODS
H influenzae
Legionella
H pylori
B fragilis
MYCOPLASMA
Mycoplasma
CHLAMYDIA
Chlamydia
OTHER
T gondii
non tuber.
Mycobacteria


CLINDAMYCIN

LINEZOLID

GRAM + COCCI
Streptococci
Staphylococci
Pneumococci
GRAM - RODS
Bacteroids
ANAEROBES
GRAM + COCCI
E fecalis (inc VR
strains)
E fecium (VR strains)
S epidermdis (MR
str)
S hemolyticus
S pneum (PR strains)
Viridans
GRAM + BACILLI
Corynebacterium
L monocytogenes
ANAEROBES
Clostridium
perfingens
OTHER
M tuberculosis


AMINOGLYCOSIDES*

* (G) = Gentamycin, (S) = Streptomycin
SULPHONAMIDES

GRAM + COCCI
Enterococcus(S)
Strept viridans(S)
Staphylococci (G)
Strep agalacteae(G)









OTHER
Mycobacterium
tuberculosis(S)
GRAM - RODS
E coli
Klebsiella
Salmonella
Shigella
Enterobacter
CHLAMYDIAS
C. trachomatis
OTHER
Nocardia
Toxoplasmosis
Plasmodium
Leishmania


TRIMETHOPRIM-SULPHAMETHOXAZOL (Cotrimoxazole)

FLUOROQUINOLONES

GRAM + COCCI
S. aureus (inc MRSA)
S. pneumoniae
GRAM - COCCI
Moraxella catarrhalis
L. monocytogenes
GRAM - RODS
Shigella
Salmonella
Hemophilus
Klebsiella
Serratia
Enterobacter
E coli
Proteus
Legionella -
pneumophila
OTHER
P jerovecii
NT mycobacteria
C. cyatenensis
Isospora belli
GRAM + COCCI
Staphylococci
(inc MRSA)
Streptococci (LEV,
GAT, MOX)
GRAM + RODS
Bacillus-
anthracis(CIP)
GRAM - COCCI
Neisseria
GRAM - RODS
E coli
Salmonella
Shigella
Enterobacter
Campylobacter
P. aeroginosa (CIP)
Legionella
Brucella
ANAEROBIC
Clostridium
MYCOPLASMA
Mycoplasma
CHLAMYDIA
Chlamydia
OTHER
M. kansasii
M. fortuitum
M. tuberculosis


CIPROFLOXACIN











GRAM + BACILLI
Bacillus anthracis
GRAM - COCCI
Neisseria gonorrheae
GRAM - RODS
Enterobacter
E coli
klebsiella
Proteus
Serratia
Shigella
Hemophilus
Legionella
P. aeroginosa
OTHER
Mycobacterium