Anda di halaman 1dari 1

Antagonisti selectivi beta 1 adrenergici

Atenolol, metoprolol, acetabutol, esmolol, bisoprolol, nebivolul, betaxolol


Caract:
-medicam cardioselective-pe beta 1
-la doze mari bronhoconstrictie pe beta 2-difera prin t
Metoprolol 3-4 ore, atenolol 6 ore, bisoprolol 10-12 ore, betaxolol 15-20 h
Efecte farmac:
-inhiba apoptoza miocardica-bisoprolol, nebivolol, metoprolol succinat=> indicatie ICC
-scade TA
-cresc toleranta la efort in angina pect
-act min la niv pul , metabolic, circ perif
Indicatii
-propanolol inclusiv la pacientii care au asociat: astm, DZ, arteriopatie
-insuf cardiaca bisoprolol, nebivolol, metoprolol succinan
Antagonisti beta adrenergici cu activitate simpatica intrinseca
Pindolo, acetabutol
Mod de act:
-se fix pe beta adrenergici=> impiedica act catecolamnielor pe ei
-stim beta dar nu cu acelasi eficienta ca a catecolaminelor
Indicatii:
-HTA+ la bolnavii cu DZ
-HTA +bradicardie
-indicatiile propanololului