PATHOPHYSIOLOGY OF

HYPERCALCEMIA
Prepared by: Carbonilla, Leda
Grace
11/26/2014

PATHOPHYSIOLOGY OF HYPERCALCEMIA
Predisposing Factors:
Age
Sex
Familial
hypocalciuric
hypercalcemia

Precipitating Factors:
Lithium
Vit D
Excessive Ca intake
Prolonged
Immobilization
Milk Alkali Syndrome

Increase bone demelirization/ bone

resorption

Excessive PTH production

Calcium levels result to cell

membrane threshold potential more
positive

Hypophospothemia

Results in cell membrane that are refactory/

cell membrane become less exitable

Delayed cell membrane

depolarization

Cardiac and smooth muscle

activity decreases
GI

Neurologic
Skeletal
Depression
Concentration
difficulty
Fatigue
Weakness
Coma
lethargy

Muscle
weakness
Fractures
Curvature of
the spine

Anorexia
Nausea
Vomiting
Abdominal
distention
constipation