Learning Outcomes
6.3.1 Define pathogen.
6.3.3 Outline the role of skin and mucous
membranes in defence against pathogens
6.3.4 Outline how phagocytic leucocytes ingest
pathogens in the blood and in body tissues.
6.3.5 Distinguish between antigens and
antibodies.
6.3.6/11.1.4 Explain antibody production
11.1 Describe the process of blood clotting
In LOTR
Minas Tirith
has large city
walls and
trebuchets
that fire
artillery at the
attacking
army to
prevent them
from entering
the city
In your body
The skin and mucous membranes prevent
pathogens from entering your body.
Skin dry, thick and tough region made of
predominantly dead surface cells. Contains
biochemical defense agents (sebaceous glands
secrete chemicals which inhibit the growth of
some bacteria). Skin also releases acidic
secretions to lower pH and prevent bacterial
growth
In your body
Mucous membranes protect internal structures
(externally accessible cavities and tubes such as
the trachea, vagina and urethra)
Thin region covering living surface cells that
release fluids to wash away pathogens (e.g.
mucous, tears, saliva, etc.)
Contains biochemical defense agents
Mucous membranes may be ciliated to aid in
removal of pathogens (along with physical actions
like coughing or sneezing)
In the body
The second line of defense against pathogenic
invasion are the non-specific defense
mechanisms.
These do not differentiate between types of
microorganisms and always invoke the same
response.
The non-specific defense mechanisms include
phagocytic leucocytes, inflammation, fever
and anti-microbial proteins.
Phagocytes
Phagocytic leucocytes (macrophages) circulate in the blood
but may move into body tissue
They concentrate at sites of infection due to the release of
chemicals (such as histamine) from damaged cells.
Pathogens are engulfed when cellular extensions surround
the pathogen and sequester it in an internal vesicle.
This vesicle may then fuse with the lysosome to digest the
pathogen
Some of the pathogens fragments may be presented on
the surface of the macrophage to stimulate antibody
production
Antibodies
Antibodies are made up of 4 polypeptide chains
(2 light and 2 heavy chains) joined together by
disulphide bonds into a Y-shaped molecule.
The ends of the arms are where the antigens bind
and these areas are called the variable regions, as
these will differ between antibodies.
Each type of antibody will recognize a unique
antigenic fragment, making this interaction
specific (like an enzyme-substrate interaction)
Antibody production
B lymphocytes (B cells) are antibodyproducing cells that develop in the bone
marrow to produce a specific antibody for an
antigen.
When macrophages encounter a pathogen,
they digest it and present the antigen
fragments on their surface to helper T
lymphocytes (helper T cells)
Antibody production
These cells activate the appropriate B cell which
divides and differentiates into short-lived plasma
cells that produce large quantities of antibody
(about 2000 molecules per second for 4-5 days)
Because pathogens may contain several antigens,
several B cell clones may become activated
(polyclonal activation)
A small proportion of B cell clones develop into
memory cells, which may survive for years and
provide long-term immunity.