AUC changes due to alteration of Clearance

High Eh Drugs
Aldosteron, Verapamil,
Chlormetiazol, Morfin,
Meperidin, Metirapon,
Hidrokortison,
Nitrogliserin
Imipramin,Nortriptilin
Isoproterenol,
Pentazosin, Metoprolol
Labetalol, Propranolol,
Fenilefrin, Lidokain,
Lorkainid, Propoksifen,
Salisilamid

These cause
increased LBF

These cause
decreased LBF

Glucagon, low-dosage
Dopamine,
Isoproterenol,
Salbutamol,
Clonidine,
Phenobarbital, PGE2

Anesthetics, Labetalol,
Propranolol, highdosage Dopamine,
Noradrenalin,
Phenylephrine,
Labetalol, Cimetidine,
Ranitidine.
Congestive Heart
failure, old age.

CL CLh = LBF
AUC = Dose/CL

Page: 210

Farmakokinetik Digoxin pada subyek

dewasa sehat dan pasien CHF
Subyek
Dewasa
normal
Pasien
dewasa
CHF

Usia
th

BB
kg

F
%

Vd
L

CLr CLh
L/jam L/jam

28

71

40 70

760

8,5

3,5

54

68

60

476

3,5

1,4

p. 189 - 198

Changes in LBF and Clearance cause alterations in

drug Concentration-Time and effect
Decreased LBF

Increased LBF