RANITIDINE

Characteristic

Cimetidine

OoA

1 hour

DoA

4-5 hours

Bioavailability

Famotidine

Nizatidine

1 hour

30 minutes

8-12 hours

10-12 hours

8-12 hours

60 20%

5525%

414%

955%
75% in renal
failure

Protein binding

206%

15%

16%

305%

Half-life

1.90.4hr

20.4hr

30.5hr

1.40.2hr

Excretion

urine

urine

urine

Urine

Renal
impairment

Hepatic
impairment

Ranitidine

ClCr :15-30
ClCr <50
mL/min:
mL/min:
600mg/day; PO 150 mg/day
or IM/IV
ClCr<15
50 mg
mL/min:
q 12-24 hr
300-400
mg/day

ClCr <10
mL/min:
20 mg/day
or 20 mg
every
other day

No dosage adjustment is needed

ClCr 20-50
mL/min :
150 mg/day;

ClCr <20
mL/min: 150
mg every
other day

Drug used in acid peptic

H2 Receptor Antagonist