Genes and Disease

Chromosome Map

Chromosome Map

Our genetic information is stored in 23 pairs of chromosomes that vary widely in size and shape.
Chromosome 1 is the largest and is over three times bigger than chromosome 22. The 23rd pair of
chromosomes are two special chromosomes, X and Y, that determine our sex. Females have a pair
of X chromosomes (46, XX), whereas males have one X and one Y chromosomes (46, XY).
Chromosomes are made of DNA, and genes are special units of chromosomal DNA. Each
chromosome is a very long molecule, so it needs to be wrapped tightly around proteins for efficient
packaging.
Near the center of each chromosome is its centromere, a narrow region that divides the
chromosome into a long arm (q) and a short arm (p). We can further divide the chromosomes using
special stains that produce stripes known as a banding pattern. Each chromosome has a distinct
banding pattern, and each band is numbered to help identify a particular region of a chromosome.
This method of mapping a gene to a particular band of the chromosome is called cytogenetic
mapping. For example, the hemoglobin beta gene (HBB) is found on chromosome 11p15.4. This
means that the HBB gene lies on the short arm (p) of chromosome 11 and is found at the band
labeled 15.4.

Genes and Disease

Chromosome Map

With the advent of new techniques in DNA analysis, we are able to look at the chromosome in
much greater detail. Whereas cytogenetic mapping gives a birds eye view of the chromosome,
more modern methods show DNA at a much higher resolution. The Human Genome Project aims to
identify and sequence the ~30,000 genes in human DNA.

Genes and Disease

Chromosome Map

Chromosome 1
Contains over 3000 genes
Contains over 240 million base pairs, of which ~90% have been determined
See the diseases associated with chromosome 1 in the MapViewer.

Genes and Disease

Chromosome Map

Chromosome 2
Contains over 2500 genes
Contains over 240 million base pairs, of which ~95% have been determined
See the diseases associated with chromosome 2 in the MapViewer.

Genes and Disease

Chromosome Map

Chromosome 3
Contains approximately 1900 genes
Contains approximately 200 million base pairs, of which ~95% have been determined
See the diseases associated with chromosome 3 in the MapViewer.

Genes and Disease

Chromosome Map

Chromosome 4
Contains approximately 1600 genes
Contains approximately 190 million base pairs, of which ~95% have been determined
See the diseases associated with chromosome 4 in the MapViewer

Genes and Disease

Chromosome Map

Chromosome 5
Contains approximately 1700 genes
Contains approximately 180 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 5 in the MapViewer.

Genes and Disease

Chromosome Map

Chromosome 6
Contains approximately 1900 genes
Contains approximately 170 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 6 in the MapViewer.

Genes and Disease

Chromosome Map

Chromosome 7
Contains approximately 1800 genes
Contains over 150 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 7 in the MapViewer.

Genes and Disease

Chromosome Map

Chromosome 8
Contains over 1400 genes
Contains over 140 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 8 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 9
Contains over 1400 genes
Contains over 130 million base pairs, of which over 85% have been determined
See the diseases associated with chromosome 9 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 10
Contains over 1400 genes
Contains over 130 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 10 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 11
Contains approximately 2000 genes
Contains over 130 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 11 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 12
Contains over 1600 genes
Contains over 130 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 12 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 13
Contains approximately 800 genes
Contains over 110 million base pairs, of which over 80% have been determined
See the diseases associated with chromosome 13 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 14
Contains approximately 1200 genes
Contains over 100 million base pairs, of which over 80% have been determined
See the diseases associated with chromosome 14 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 15
Contains approximately 1200 genes
Contains approximately 100 million base pairs, of which over 80% have been determined
See the diseases associated with chromosome 15 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 16
Contains approximately 1300 genes
Contains approximately 90 million base pairs, of which over 85% have been determined
See the diseases associated with chromosome 16 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 17
Contains over 1600 genes
Contains approximately 80 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 17 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 18
Contains over 600 genes
Contains over 70 million base pairs, of which over 95% have been determined
See the diseases associated with chromosome 18 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 19
Contains over 1700 genes
Contains over 60 million base pairs, of which over 85% have been determined
See the diseases associated with chromosome 19 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 20
Contains over 900 genes
Contains over 60 million base pairs, of which over 90% have been determined
See the diseases associated with chromosome 20 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 21
Contains over 400 genes
Contains over 40 million base pairs, of which over 70% have been determined
See the diseases associated with chromosome 21 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome 22
Contains over 800 genes
Contains over 40 million base pairs, of which approximately 70% have been determined
See the diseases associated with chromosome 22 in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome X
Contains over 1400 genes
Contains over 150 million base pairs, of which approximately 95% have been determined
See the diseases associated with chromosome X in the MapViewer.

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Genes and Disease

Chromosome Map

Chromosome Y
Contains over 200 genes
Contains over 50 million base pairs, of which approximately 50% have been determined
See the diseases associated with chromosome Y in the MapViewer.

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