DATA ANALGETIK

TRAMADOL

ASPIRIN

NA CMC

PERL
AKUA
N

JUMLAH GELIAT
1 1 2 2
5 0 5 0 5
MENCIT/MENIT KE' ' ' ' '
1 2 2 3
1
5 4 0 8 0
2 2 2 2
2
5 7 3 1 0
1 1 2 1 2
3
7 2 2 7 5
1 1 1 1 1
4
5 5 3 3 0
1 2 2 1 1
5
6 8 0 7 5
1 5 2 3 5
6
7 1 8 3 5
JUMLAH GELIAT KUMULATIF
1
0 0 3 2 0

TOTA
L
GELIA
T
3
0
'
3
4
1
7
2
1

3
5
'
3
5
1
5
2
3

4
0
'
4
2
1
3
3
0

4
5
'
3
7
1
2
2
4

4
1
5
2
1

4
1
5
1
8

8 3 5 5
1
1
2 9 8 3
1
1 8 5 7

4
1
2

103

0
1
2
6 8 5 9 8 3
3 2 1 1 2
3
5 0 5 6 5 5
1 1 1
4
0 5 2 9 5 9
1 1 1
5
9 7 6 8 9 5
1 1 1 1 1
6
5 3 0 2 5 3
JUMLAH GELIAT KUMULATIF
1 1
1
9 5 4 7 6 5
2
2
4 9 7 7 5 2
3
5 4 6 5 6 4
4
3 3 2 4 2 1
1 1 2 1
5
4 6 3 0 3 4
6
3 5 1 7 3 4
JUMLAH GELIAT KUMULATIF

5
1
0
1
0

6
1
5
2
0

1
1
1

265
1377
23

3
1
3
1
4

5
0
'
3
5
1
3
2
9

2
1
2
1
6

5
5
'
3
5

6
0
'
3
3

8 8
3 3
3 5

1
1
5
1
0

349
184
291

185

125
194

3 1 0 0 0 0

64

6 7 3 1 0 0
1
2 1 1 1 2 2

91
87
584

3 7 3 0 4 0

73

3 2 1 2 0 3
2 0 1 1 0 2
3 0 2 0 0 0

65
36
20

1 5 2 4 0 0
2 1 0 0 0 0

82
26
302

JUMLAH GELIAT
KUMULATIF

PERLAKUAN
NA CMC
ASPIRIN
TRAMADOL

ANALGETIKUM
1600
J
U 1400
M 1200
L
A 1000
H
800
G
E
L
I
A
T

600
400
200
0
NA CMC

ASPIRIN

TRAMADOL

PERLAKUAN

DATA AUC :
Na.CMC

AU
C
510

AU
C
510

AU
C
1015

AU
C
1520

AU
C
2530
10
3
71

AU
C
3035
12
2
55

AU
C
3540
14
0
48

AU
C
4045

76

AU
C
2025
10
3
71

25

AU
C
4550
12
5
45

13

40

64

90

13

73

85

43

47

67

65

80

80

79

98

54

97

38
40
43

53
86
14

48
78
12

46
63
11

38
55
17

38
55
17

14
53
66

24
45
46

11
21
19

16
29
21

79

AU
C
5055
12
3
33
11
2
18
41
23

AU
C
5560
11
8
28
12
1
15
43
20

AUC
TOT
AL
130
620
939
356
607
953

Aspirin

AU
C
510
0
15
13
25
23
13

AU
C
510
7.5
21
93
45
57
38

AU
C
1015
7.5
21
93
45
57
38

AU
C
1520
8
28
65
35
61
40

AU
C
2025
2
29
54
22
41
50

AU
C
2530
0
41
78
28
22
48

AU
C
3035
13
38
50
17
20
43

AU
C
3540
20
48
60
5.5
24
15

AU
C
4045
14
48
55
1
15
3.5

AU
C
4550
8
43
54
0
5.5
3.5

AU
C
5055
4.5
50
41
0
1
6

AU
C
5560
3.5
43
30
0
0
7

Tramadol

AU
C
510
23
10
13
7.5
35
7.5

AU
C
510
47
77
15
11
54
16

AU
C
1015
50
47
19
8
74
7.5

AU
C
1520
32
25
19
12
48
19

AU
C
2025
22
20
20
9
18
15

AU
C
2530
19
10
16
4.5
13
13

AU
C
3035
13
9.5
9
8.5
6.5
9

AU
C
3540
15
4.5
2.5
5
10
1

AU
C
4045
15
4.5
2.5
5
10
1

AU
C
4550
3
6
3.5
2
12
0

AU
C
5055
10
2
1
0
4
0

AU
C
5560
4
7.5
5
0
0
0

ANOVA
GELIAT

Between Groups
Within Groups
Total

Sum of
Squares
103555.44
4
59718,167
163273.61
1

df

Mean Square
2

51777,722

15

3981,211

17

GELIAT
Duncan
N
PERLAKUAN
TRAMADOL
ASPIRIN
CMC
Sig.

Subset for alpha = .05

1
6
6
6

2
50,3333
97,3333

229,5000

,217
1,000
Means for groups in homogeneous subsets are displayed.

F
13,006

Sig.
,001

AUC
TOT
AL
87
421
684
222
324
303
AUC
TOT
AL
250
221
125
72
284
88

a Uses Harmonic Mean Sample Size = 6,000.

HIPOGLIKEMIA

NA CMC

PERLAKUA
N

KADAR GULA
TIKUS/MENIT
KE0'
60'
1
2
3

89
82
88

87
88
98

110

84

5
6

108
84

93

87
87
10
0

83

96

99
10
3

10

1
2
3

80
91.
3
104
89
98

99
93.
2
89
84
96

4
5
6

103
93
81

99
94
99

7
8

94
91

95
84
93
10
0
85

9
10

105
80
93.
8
103
98

87
86
89.
9
97
99

88
82
90.
2
89
10
2

GLIBENKLAMID

RATA-RATA

RATA-RATA
METFO
RMIN

90'
10
2
84
88

1
2

99
10
0
90
87
10
5
10
1
10
8
96.
4
87
88
91

87
87

15
0'
87
82
88
10
6
88
83
87
10
2
85
81
88.
9
81
82
92
10
1
84
88
83
86
10
0
82
87.
9
81
87

RATA-RATA

INTERVAL
WAKTU/MENIT
NA CMC
GLIBENKLAMID
METFORMIN

NA CMC

GLIBENKLAMID

10
1

105

104

5
6
7
8

109
106
94
105

93

89
10
1
81
85
85
10
7

10

94
101
.1

86
93.
1

81
10
1
11
0
80
87
97
82
10
6
93.
5

10
2
10
6
89
89
98
84
87
94
91.
7

0'
91.3
93.8
101.1

60'
93.2
89.9
93.1

90'
96.4
90.2
93.5

150'
88.9
87.9
91.7

AUC 060
2699
2722
3028
2630
2718
2694
3093
3053
3186
3050

AUC 6090
1617
1348
1418
1569
1587
1437
1405
1674
1618
1719

AUC 90150
2712
2544
2728
3279
2740
2580
2697
3165
2651
2538

AUC Total
7028
6614
7174
7478
7045
6711
7195
7892
7455
7307

AUC 060
2774
2609
2978
2953

AUC 6090
1394
1404
1461
1580

AUC 90150
2517
2548
2851
3129

AUC Total
6685
6561
7290
7662

METFORMIN

2613
2871
3094
2641
2715
2660

1494
1578
1405
1390
1407
1316

2614
2739
2577
2667
3088
2542

6721
7188
7076
6698
7210
6518

AUC 060
3013
3068
3135
2774
3139
2536
2644
2655
3303
2674

AUC 6090
1432
1629
1316
1604
1751
1281
1390
1540
1337
1676

AUC 90150
2519
2712
3141
3281
2780
2750
3027
2617
2692
2926

AUC Total
6964
7409
7592
7659
7670
6567
7061
6812
7332
7276

ANOVA
KGD

Between Groups
Within Groups
Total

Sum of
Squares
38,827
102,050
140,877

KGD
Duncan

df
2
9
11

Mean Square
19,413
11,339

F
1,712

Sig.
,234

Subset for
alpha = .
05
PERLAKUAN
GLIBENKLAMID
CMC

N
1

METFORMIN

4
4

1
90,4500
92,4500

94,8500

Sig.

,111
Means for groups in homogeneous subsets are displayed.
a Uses Harmonic Mean Sample Size = 4,000.

ANTI INFLAMASI :

NA CMC

PERLAKUA
N

VOUME UDEMA
TIKUS/MENIT
KE1
2
3
4
5
6

NA DIKLOFENAK

RATA-RATA
1
2
3
4
5
6

PARASETAMOL

RATA-RATA

RATA-RATA

1
2
3
4
5
6

0'
2
5
7
9
6
7
6.0
4
4
5
5
3
0
3.5
3
8
5
3
9
0
4.7

60'
7
6
15
6
9
6
8.2
8
13
9
7
4
5
7.7
4
4
9
2
5
5
4.8

90'
8
8
8
8
6
9
7.8
7
15
12
9
7
6
9.3
6
15
8
0
8
6
7.2

120'
4
1
8
8
7
10
6.3
3
8
7
12
12
3
7.5
2
12
8
7
9
3
6.8

150'
3
8
8
9
8
10
7.7
3
8
9
2
7
7
6.0
3
6
5
5
4
7
5.0

180'
6
6
7
6
5
7
6.2
8
7
4
4
9
5
6.2
8
7
4
3
2
5
4.8

INTERVAL
WAKTU/MENIT
NA CMC
NA DIKLOFENAK
PARASETAMOL

0'

60'

90'

120'

150'

6.0
3.5
4.7

8.2
7.7
4.8

7.8
9.3
7.2

6.3
7.5
6.8

7.7
6.0
5.0

ANTIINFLAMASI
10.0
9.0
V
O
L
U
M
E

8.0

U
D
E
M
A

4.0

7.0
6.0
5.0

NA CMC

NA DIKLOFENAK

PARASETAMOL

3.0
2.0
1.0
0.0
0'

60'

90'

120'

INTERVAL WAKTU

150'

180'

180
'
6.2
6.2
4.8

DATA AUC :

Na. CMC

%
Rada
ng
60'
6
5
14
5
8
5

%
Rada
ng
90'
7
7
7
7
5
8

%
Rada
ng
120'
3
0
7
7
6
9

%
Rada
ng
150'
2
7
7
8
7
9

%
Rada
ng
180'
5
5
6
5
4
6

Na. Diklofenak

%
Rada
ng
60'
7
12
8
6
3
0

%
Rada
ng
90'
6
14
11
8
6
5

%
Rada
ng
120'
2
7
6
11
11
2

%
Rada
ng
150'
2
5
4
4
3
6

%
Rada
ng
180'
7
6
3
3
8
4

Vitamin K

%
Rada
ng
60'
3
3
8
1
4

%
Rada
ng
90'
5
14
7
-1
7

%
Rada
ng
120'
1
11
7
0
8

%
Rada
ng
150'
2
5
4
4
3

%
Rada
ng
180'
7
6
3
2
1

AUC
TOTA
L
23
24
41
32
30
37

AUC
TOTA
L
24
44
32
32
31
17

AUC
TOTA
L
18
39
29
6
23

ANOVA
UDEM

Between Groups
Within Groups
Total

Sum of
Squares
13,534
28,108
41,643

df
2
15

Mean Square
6,767
1,874

17

UDEM
Duncan
N
PERLAKUAN
PARASETAMOL
NA DIKLOFENAK
CMC
Sig.

Subset for alpha = .05

1
6
6
6

2
5,0500
6,7000

1
6,7000
7,0333

,054
,679
Means for groups in homogeneous subsets are displayed.
a Uses Harmonic Mean Sample Size = 6,000.

F
3,611

Sig.
,052