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Tongue
Vestibular lamina
Dental lamina
Tooth bud
Tongue
Dentai larnina
Tooth bud
Developing mandibular
bone
Fig*r*:.i-1* Bud
stage of
tooth devel*pnrerrt sren in coronal secii$n tA) and sagiltal section (B).
orre
r-rt'
th* i:uil
mescachym.e is rccluireil
ttr rnainririn BnrJ:-? anrt Shh explessicrn ir-l the r:pitheliirrn.
Lr.rss *1'- Iirrp-4 expression in trfs::-i rnutants is acconrpn*
nied hy lass o{ Sllh exl.ressi,rn rt E12.5, rvhich c*n he
Bmp-4 expresser{ in