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  • Dr. Rajendran'S Institute of Medical Education: Dopamine and Dobutamine

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    suckeydluffy
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    Dopamine and dobutamine are sympathomimetic agents that act on different receptor types to varying degrees. Dopamine is a nonselective adrenergic and dopaminergic agonist that is produced in the body and acts as a neurotransmitter. At low doses from 0.5-4 mcg/kg/min, dopamine causes vasodilation in the renal, mesenteric, coronary, and intracerebral vasculatures by stimulating D1 receptors and increasing cyclic AMP levels. Dobutamine is a selective β1 receptor agonist that also stimulates β2 receptors at higher doses and is used to increase cardiac contractility and output.

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    Dopamine and dobutamine are sympathomimetic agents that act on different receptor types to varying degrees. Dopamine is a nonselective adrenergic and dopaminergic agonist that is produced in the body and acts as a neurotransmitter. At low doses from 0.5-4 mcg/kg/min, dopamine causes vasodilation in the renal, mesenteric, coronary, and intracerebral vasculatures by stimulating D1 receptors and increasing cyclic AMP levels. Dobutamine is a selective β1 receptor agonist that also stimulates β2 receptors at higher doses and is used to increase cardiac contractility and output.

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    9 tayangan2 halaman

    Dr. Rajendran'S Institute of Medical Education: Dopamine and Dobutamine

    Diunggah oleh

    suckeydluffy
    Dopamine and dobutamine are sympathomimetic agents that act on different receptor types to varying degrees. Dopamine is a nonselective adrenergic and dopaminergic agonist that is produced in the body and acts as a neurotransmitter. At low doses from 0.5-4 mcg/kg/min, dopamine causes vasodilation in the renal, mesenteric, coronary, and intracerebral vasculatures by stimulating D1 receptors and increasing cyclic AMP levels. Dobutamine is a selective β1 receptor agonist that also stimulates β2 receptors at higher doses and is used to increase cardiac contractility and output.

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    dari 2

    Page 1 of 2

    Dr. RAJENDRANS INSTITUTE OF MEDICAL EDUCATION

    DOPAMINE AND DOBUTAMINE

    SYMPATHOMIMETIC AGENTS

    Receptor Type

    Dopamine

    ++++

    ++

    receptors
    0

    ++/+++

    ++++

    ++

    ++++

    +++

    ++++

    +++

    Norepinephrine

    ++++

    ++++

    Phenylephrine

    ++/+++

    Dobutamine
    Dopamine
    Epinephrine

    DOPAMINE
    Dopamine is the immediate metabolic precursor of norepinephrine and epinephrine. Dopamine
    is a nonselective adrenergic and dopaminergic agonist. It is a central neurotransmitter
    particularly important in the regulation of movement. In the periphery, it is synthesized in
    epithelial cells of the proximal tubule and exerts local diuretic and natriuretic effects.
    ACTIONS

    It acts on dopaminergic, 1- and -adrenergic receptors. Its effects vary markedly with the
    dose.

    www.medicinemcq.com

    Page 2 of 2

    Low doses (0.54 mcg/kg/min)


    At low concentrations (0.54 mcg/kg/min), the primary interaction of dopamine is with vascular
    D1 receptors, especially in the renal, mesenteric, and coronary beds. By activating adenylyl
    cyclase and raising intra-cellular concentrations of cyclic AMP, D1 receptor stimulation leads
    to vasodilation.
    In low doses (0.5 to 4.0 micrograms/kg/min), dopamine causes vasodilation in the renal,
    mesenteric, coronary, and intracerebral vasculatures via stimulation ..

    For complete article, click 'premium content' > Cardiology.

    Morgan & Mikhail's Clinical Anesthesiology, 5e > Chapter 14. Adrenergic Agonists &
    Antagonists > Adrenergic Agonists

    Tintinalli's Emergency Medicine > Chapter 24. Pharmacology of Vasopressor Agents >
    Vasoactive Drug

    Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e > Chapter 12.
    Adrenergic Agonists and Antagonists >

    www.medicinemcq.com

    Adrenergic Receptor Agonists

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