INVESTIGATION OF

SYSTEMIC LUPUS
ERYTHEMATOSUS (SLE)
Systemic lupus erythematosus (SLE)
is a chronic inflammatory
autoimmune disease. It can affect
nearly every organ system in the
body which the symptoms may vary
widely between individuals
By : Nuramalina Yahaya (10-5-257)

STANDARD LABORATORY
STUDIES
1. Complete blood count(CBC)
. Leukopenia, lymphopenia, anemia,
thrombocytopenia
. Prolonged partial activated thromboplastin
(aPTT )
2. Serum creatinine
. Kidney affection
3. Urinalysis
. Low serum albumin, persistent proteinuria
. Red and white cell cast

OTHER LABORATORY TEST

1. ESR or CRP
. Elevated due to increase activity of
infectious process
2. Complement level
. Decrease C3 and C4 in active SLE
3. Liver function test
. Mildly elevated in acute SLE
4. Creatine kinase assay
. Increase in myosities and overlap syndromes
5. Spot protein / spot creatinine ratio