Risk factor

-travel to/living in high risk area

Bite of Aedes Aegypti

(saliva contains virus)

DENV penetrate the skin

Virus infect Dendritic Cells

Infected DC enter lymphatic circulation

fever pyrogen

Produce cytokine & become APC

B cell produce antiNS1-Ab IgM & IgG

Cytotoxic T cel recognize & kill infected cell

Virus infect and replicate within

monocyte & macrophage

Infected monocyte & m travel in

circulation (Viremia)

Vasoactive cytokine
Increase vascular permeability
Plasma leakage
Hypovolemia
Haemoconcentration

Directly infect bone marrow

Bone marrow suppression

NK cell kill virus-infected cells

Virus-antibody Complex

Activation of complement

Destruction of platelet

http://www.nature.com/scitable/topicpage/host-response-to-the-dengue-virus-22402106
http://www.hindawi.com/journals/isrn/2013/571646/

http://bestpractice.bmj.com/best-practice/monograph/1197/basics/pathophysiology.html
http://www.authorstream.com/Presentation/jupitar20999-314140-dengue-fever-science-technology-ppt-powerpoint/
http://www.antimicrobe.org/new/v34.asp