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Jurnal SPO halaman 136

Hasil dan diskusi


Persiapan tablet pantoprazole
Tablet Pantoprazol disusun dengan metode granulasi basah. dalam penelitian ini,
tablet disusun menggunakan HPMC, pati singkong, dan PVP sebagai rilis hidrofilik
perlambatan polimer dalam konsentrasi yang berbeda. selama optimasi dari
butiran, massa sluggy kelembaban rendah ditemukan memiliki lebih banyak denda
dan kerapuhan yang tinggi dan massa sluggy kelembaban tinggi yang lengket
dalam proses pemisahan. Oleh karena itu, air optimum (pasta 5%) adalah
penggunaan untuk mempersiapkan butiran. butiran yang diperoleh halus dan
hampir seragam ukuran.
Karakterisasi tablet pantoprazole
precompression dan pasca kompresi parameter. butiran pnatoprazole dievaluasi ada
menghasilkan, ukuran butiran partikel, sudut diam, bulk density, kepadatan
disadap, dan kompresibilitas dan hasilnya diberikan dalam tabel III. hasil dari
butiran berkisar menjadi tween 86 dan 98%. ini bisa concidered nilai hasil yang
memuaskan dan karena polimer sifat mengikat butiran.
Result and discussion
Preparation of pantoprazole tablets
Pantoprazol tablets were prepared by the wet granulation method. in this study,
tablet were prepared using HPMC, cassava starch, and PVP as hydrophilic release
retarding polymers in different concentrations. during optimization of the granules,
low moisture sluggy masses were found to have more fines and high friability and
the high moisture sluggy masses were sticky in the sieving process. Hence,
optimum moisture (paste 5 %) was use for preparing the granules. the obtained
granules were smooth and almost uniformly sized.
Characterization of pantoprazole tablets
precompression and post compression parameters. pnatoprazole granules were
evaluated for there yield, granule particle size, angle of repose, bulk density, tapped
density, and compressibility and the results are given in the table III. the yield of
granules ranged be tween 86 and 98 %. this could be concidered a satisfactory yield
value and was due to polymer binding properties of granules.