DRUG USED FOR

A groupPARKINSONS
of chronic CNS disordersDISEASE
characterized by
recurrent seizures.

Seizures are symptoms of an abnormality in the nerve

centers of the brain. They are briefs periods of abnormal
electrical activity in the brain. Brain dysfunction
resulting from abnormal discharge of neuronal cells with
associated motor, sensory or behavioral changes.

dr. Agung Wiwiek Indrayani, M.Kes

Department of Pharmacology
Udayana University

PARKINSONS DISEASE
A progresive neurologic disorder caused by
deterioration of dopamine-producing cells in the
portion of the brain responsible for maintenance of
posture and muscle tone and the regulation of
smooth muscles
The goal of treatment is to restore dopamine
neurotransmitter function as close to normal as
possible and relieve symptoms caused by
excessive acetylcholine

ANTIPARKINSON DRUGS
Therapy must be individualized, but selegiline therapy
is often started first to slow the development of symptoms
As selegiline become less effective, levodopa is started with or
without selegiline
Dopamine agonists (amantadine, bromocriptine,pergolide,
Ropinirole,pramipexole) used to directly stimulate dopamine
receptors
Entacapone may added to levodopa therapy to reduce
the metabolism of levodopa, prolonging its action
Anticholinergic agents may be added at any time to reduce the
Effects of the excessive acetylcholine