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Physiology of

Gustation
PBL 1.6 Taste Buddy

How does it work?


Via sensory transduction.
1. Chemicals bind to taste receptor cells.
2. Excitation of voltage-gated Na +, K+, and
Ca2+channels (DEPOLARIZATION) can
generate action potentials
3. These currents open the voltage-gated
Ca2+channels near the base of the taste cells
4. Neurotransmitters are released
5. Produces action potentials in afferent
nerve fibres signals sent to brain

1. Mediated by Na+ions which diffuse


through a Na+channel located in the
microvilli.
2. The influx of these ions of salt evokes a
depolarization in the apical membrane

Saltine
ss

1. The hydrogen proton of acids and sour foods influx


through Na+channels, or through a proton transport
membrane protein.
2. Some acids block the efflux of K+.
3.
The influx of protons or a reduction in
K+conductance will initiate receptor potentials in
response to the quality of sour tastes.

Sourne
ss

Sweetness

Bitterness
1) Blockage of the efflux of K+by
bitter substances causes
DEPOLARIZATION

Thus releasing Ca2+, an


action potential will be
fired.

Umami
Interacts with a ligand-gated
inotropic glutamate receptor coupled
to gustducin and Ca2+channel
membrane proteins.

1. Cranial nerves
innervated
2. Cranial nerves
terminate on 2ndorder
sensory neurons in
the nucleus of the
solitary tract
3. Fibers of the
2ndorder neurons
travel through the
ipsilateral central
tegmental tract to the
3rdorder sensory
neurons in the VPM of
the thalamus
4. VPM projects to the
ipsilateralgustatory
cortex or insular
cortex

Gustatory
Tract

Smell and Taste


Taste: A compound sensation produced by
taste and smell receptors
Taste receptors: Specialized cells that
detect chemicals present in the mouth itself
Smell receptors: Modified sensory neurons
in nasal passages that detect vapors from
distant sources x3400 more sensitive
** Hot foods have more taste than cold foods,
because they vaporize more

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