Scribd Logo
Unggah

Selamat datang di Scribd!

  • Blood supply and hormone secretion in the islets of Langerhans

    Diunggah oleh

    Teresa Martins
    15 tayangan1 halaman
    The document summarizes the structure and function of the islets of Langerhans in the pancreas. It describes the islets as clusters of endocrine cells that make up 1-2% of the pancreas and contain different cell types including alpha, beta, delta, and F cells. The beta cells are located in the inner core and secrete insulin, while the alpha cells are on the outer mantle and secrete glucagon. Together insulin and glucagon work to regulate blood glucose levels.

    Deskripsi Asli:

    .

    Judul Asli

    Iselets of Langerhans

    Hak Cipta

    © © All Rights Reserved

    Format Tersedia

    PDF, TXT atau baca online dari Scribd

    Apakah menurut Anda dokumen ini bermanfaat?

    Apakah konten ini tidak pantas?

    Laporkan Dokumen Ini
    The document summarizes the structure and function of the islets of Langerhans in the pancreas. It describes the islets as clusters of endocrine cells that make up 1-2% of the pancreas and contain different cell types including alpha, beta, delta, and F cells. The beta cells are located in the inner core and secrete insulin, while the alpha cells are on the outer mantle and secrete glucagon. Together insulin and glucagon work to regulate blood glucose levels.

    Hak Cipta:

    © All Rights Reserved
    Unduh sebagai PDF, TXT atau baca online dari Scribd
    Tandai sebagai konten tidak pantas
    15 tayangan1 halaman

    Blood supply and hormone secretion in the islets of Langerhans

    Diunggah oleh

    Teresa Martins
    The document summarizes the structure and function of the islets of Langerhans in the pancreas. It describes the islets as clusters of endocrine cells that make up 1-2% of the pancreas and contain different cell types including alpha, beta, delta, and F cells. The beta cells are located in the inner core and secrete insulin, while the alpha cells are on the outer mantle and secrete glucagon. Together insulin and glucagon work to regulate blood glucose levels.

    Hak Cipta:

    © All Rights Reserved
    Unduh sebagai PDF, TXT atau baca online dari Scribd
    Tandai sebagai konten tidak pantas
    dari 1

    Blood Supply is "Core-to-Mantle" and carries "Secretogogues" (like glucose) from Inside to Outside

    "Insulo-Acinar Portal System" >>> Portal Vein >>> Liver


    > Glucagon >>> Insulin
    > Insulin >>> Insuline (Autocrine)
    > Insulin ---x Glucagon
    > Somatostatin ---x (Insulin + Glucagon)
    SS~R~Exocrine Cells ---x HCO3 + Digestive Enzymes

    Islets of Langerhans
    Cell Morphology

    > made for regulated secretion of peptide hormones


    > Large RER, prominentn Golgi, Storage Granules (Dense-Core Secretory vesicles with HALOs) glycoprotein

    Innervation: Sympathetic + Parasympathetic, 10% of cells are Synapsed Upon


    > Gap Junctions between B-Cells

    Cell Types in the Islets of Langerhans


    Alpha:
    Beta:
    Delta
    F-cell

    15-20%
    70%
    <5%
    rare

    Glucagon
    @ Outer Mantle
    Insulin
    @ Inner Core
    Somatostatin @ Outer Mantle
    Pancreatic PPT

    Islets of Langerhans

    > Clusters of Rounded Endocrine cells amougst the Exocine Pancreas


    > 1-2% of total volume of pancrease, 500K/pancreas

    Function

    1) Regulate Serum Glucose


    > Insulin: lowers blood sugar
    > Glucagon: raises blood sugar
    2) Somatostatin
    3) VIP
    4) 5HT
    6) Amylin
    7) Pancreatic Polypeptide

    D
    F

    Insulin

    on
    cag

    n
    ati

    Glu

    Ins

    Blo

    t
    tos
    ma

    uli

    od

    So

    Flo
    w

    Glucagon

    Somatostatin

    To Portal Vein

    Anda mungkin juga menyukai