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DAFTAR ISI

ABSTRAK ....................................................................................................
ABSTRACT ...................................................................................................
KATA PENGANTAR ..................................................................................
DAFTAR ISI ................................................................................................
DAFTAR TABEL .........................................................................................
DAFTAR LAMPIRAN ................................................................................

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BAB 1 PENDAHULUAN ............................................................................


1.1 Latar Belakang ......................................................................
1.2 Rumusan Masalah ................................................................
1.3 Tujuan Penelitian ..................................................................
1.3.1 Tujuan Umum ..........................................................
1.3.2 Tujuan Khusus ..........................................................
1.4 Manfaat Penelitian ................................................................

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BAB 2 TINJAUAN PUSTAKA ...................................................................


2.1 Definisi Tuberkulosis Paru ...................................................
2.2 Sejarah Tuberkulosis ............................................................
2.3 Ciri dan Sifat Mikobakterium................................................
2.4 Fisiologi Paru.........................................................................
2.5 Patogenesis Tuberkulosis Paru..............................................
2.6 Manifestasi Klinis..................................................................
2.7 Pemeriksaan Tuberkulosis.....................................................
2.8 Penegakkan Diagnosis TB Paru............................................
2.9 Penatalaksanaan TB Paru......................................................
2.10 Penggolongan Obat Antituberkulosis..................................
2.11 Isoniazid...............................................................................
2.11.1 Aktivitas Antibakteri ..............................................
2.11.2 Farmakokinetik ......................................................
2.11.3 Efek Samping..........................................................
2.11.4 Status dalam Pengobatan.........................................
2.12 Rifampisin...........................................................................
2.12.1 Aktivitas Antibakteri...............................................
2.12.2 Farmakokinetik.......................................................
2.12.3 Efek Samping..........................................................
2.12.4 Status dalam Pengobatan........................................
2.13 Pirazinamid..........................................................................
2.13.1 Aktivitas Antibakteri...............................................
2.13.2 Farmakokinetik.......................................................
2.13.3 Efek Samping..........................................................
2.13.4 Status dalam Pengobatan........................................
2.14 Etambutol............................................................................
2.14.1 Aktivitas Antibakteri...............................................

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2.14.2 Farmakokinetik.......................................................
2.14.3 Efek Samping..........................................................
2.14.4 Status dalam Pengobatan........................................
2.15 Streptomisin.........................................................................
2.15.1 Aktivitas Antibakteri...............................................
2.15.2 Farmakokinetik.......................................................
2.15.3 Efek Samping..........................................................

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BAB 3 KERANGKA KONSEPTUAL DAN HIPOTESIS ....................... 28


3.1 Kerangka Konseptual ........................................................... 28
3.2 Hipotesis ............................................................................... 28
BAB 4 METODE PENELITIAN ...............................................................
4.1 Jenis Penelitian .....................................................................
4.2 Lokasi dan Waktu Penelitian ................................................
4.3 Populasi dan Sampel Penelitian ............................................
4.3.1 Populasi Penelitian ...................................................
4.3.2 Sampel Penelitian .....................................................
4.4 Variabel Penelitian dan Definisi Operasional .......................
4.4.1 Variabel Penelitian ...................................................
4.4.2 Definisi Operasional ................................................
4.5 Metode Pengukuran Data .....................................................
4.6 Metode Analisis Data ...........................................................

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BAB 5 HASIL PENELITIAN .....................................................................


5.1 Deskripsi Lokasi Penelitian ..................................................
5.1.1 Gambaran Umum dan Letak Geografis ...................
5.1.2 Kepegawaian dan Tenaga Kerja ...............................
5.2 Hasil Penelitian .....................................................................
.................................................................................................37
5.2.1 Distribusi Frekuensi Subjek Penelitian Berdasarkan
Umur.........................................................................
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5.2.2 Distribusi Frekuensi Subjek Penelitian Berdasarkan
Jenis Kelamin...........................................................
..............................................................................37
5.2.3 Distribusi Frekuensi Subjek Penelitian Berdasarkan
Status Pekerjaan........................................................
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5.2.4 Distribusi Frekuensi Subjek Penelitian Berdasarkan
Riwayat Penyakit......................................................
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5.2.5 Distribusi Frekuensi Subjek Penelitian Berdasarkan
Riwayat Pengobatan.................................................
..............................................................................38

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5.2.6 Distribusi Frekuensi Subjek Penelitian Berdasarkan


Gejala Ikterik yang Muncul......................................
..............................................................................39
5.2.7 Nilai T dan P pada Uji T Sampel Berpasangan.........
..............................................................................40
BAB 6 PEMBAHASAN ..............................................................................
....................................................................................................................42
6.1 Pengaruh Obat Antituberkulosis (OAT) Terhadap Faal Hati
Pasien TB Paru Selama 2 Bulan Pengobatan .....................
..........................................................................................42
6.2 Keterbatasan Penelitian .......................................................
..........................................................................................44
BAB 7 KESIMPULAN DAN SARAN .......................................................
....................................................................................................................45
7.1 Kesimpulan ...........................................................................
.................................................................................................45
7.2 Saran .....................................................................................
.................................................................................................45
DAFTAR PUSTAKA
LAMPIRAN

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