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Cystic Fibrosis is an inherited life-threatening disorder that damages the lungs and digestive system. CF causes the body to produce abnormally thick mucus that clogs internal pathways. The goal of this study was to research the differences in the digestive tract microbiota between children with CF and healthy individuals.
Cystic Fibrosis is an inherited life-threatening disorder that damages the lungs and digestive system. CF causes the body to produce abnormally thick mucus that clogs internal pathways. The goal of this study was to research the differences in the digestive tract microbiota between children with CF and healthy individuals.
Cystic Fibrosis is an inherited life-threatening disorder that damages the lungs and digestive system. CF causes the body to produce abnormally thick mucus that clogs internal pathways. The goal of this study was to research the differences in the digestive tract microbiota between children with CF and healthy individuals.
Can probiotics help children with cystic fibrosis?
The Summary for
Patients is intended for patients to better understand the complicated and often mystifying language of modern medicine. Summaries for Patients are presented for informational purposes only. These summaries are not a substitute for advice from your own medical provider. If you have questions about this material, or need medical advice about your own health or situation, please contact your physician.
The full report is titled
Bruzzese, Eugenia, et al. Disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with Lactobacillus GG: a randomized clinical trial. PlaS one 9.2 (2014): e87796. This summary was written by, Caitlin George, Sodexo Dietetic Intern And was reviewed by Robert Zurfluh RDN, and Alison Reyes, MS, RD March 2015
What is the problem and what is known about it so far?
Cystic Fibrosis (CF) is an inherited life-threatening disorder that damages the lungs and digestive system. This disorder causes the body to produce abnormally thick mucus that clogs a number of internal pathways and therefore inhibits organs from working properly. This disease slowly leads to damage of the digestive system and lung function of these patients to the point where lung transplants are needed for them to survive. Why did the researchers do this particular study? The goal of this study was to research the differences in the digestive tract microbiota between children with CF and healthy individuals. The digestive tract microbiota is a complex species of bacteria that lives within the digestive tract, and depending on what type of bacteria is present can improve health or disable health. The researchers also wanted to look at the relationship between the microbiota and intestinal inflammation. Overall, they wanted to see how supplementation with Lactobacillus GG, a probiotic, affects the microbiota and lung function. Probiotics are known to restore the healthy bacteria found in the digestive tract. Who was studied? There were twenty-two clinically stable children with CF that were enrolled in the study. The median age was seven years old with thirteen males and nine females. The participants had to have no acute diseases or have taken antibiotics or steroids within the two weeks prior to the start of the trial. There were also twenty healthy individuals used to compare the digestive tract microbiota between them and the CF patients. How was the study done? This was a randomized double blind clinical trial. The twenty-two participants were assigned to the treatment group (10) that received the probiotic supplement or the placebo group (12) that received an identical looking placebo (a fake supplement, e.g. a sugar pill. All participants were given one pill a day for four weeks. They tested the digestive tract microbiota before the study started to compare the bacteria found in the CF patients compared to the healthy participants. They also assessed both groups intestinal inflammation using specific biomarkers that are found in the fecal matter. After the four-week period of supplementation, the researchers compared the digestive tract microbiota and lung function between the treatment group and the placebo group. What did the researchers find? The researchers found that the CF patients had significantly higher amounts of intestinal inflammation compared to the healthy individuals. Also, many of the beneficial microbiota species were missing in the CF patients, when compared to the healthy controls. When comparing the treatment vs. placebo groups, the children who were treated with the probiotic had a significant increase in the healthy intestinal bacteria and showed a significant decrease in intestinal inflammation. The researchers stated that this function could help decrease lung infections and improve lung function in the CF patient. What were the limitations of the study? The limitations of this study were that they used a very small group of people. The researchers also did not state how they recruited both the CF participants and healthy participants for the study, and it was not mentioned where the study was done. Finally, they did not explain how the probiotics affect lung function in a direct manner. They just explained the intestinal inflammation, and microbiota diversity in detail, and just stated that the beneficial changes in the digestive tract will improve lung function. What are the implications of the study? This study suggests that children with CF who take a probiotic supplement can improve their digestive tract health and may improve their lung function.