Understand human embryo

process, abnormality, and

prevention techniques

1. Langmans Medical Embryology, T.W. Sadler,

1997
2. Embryology Atlas, Ulrich Drews, 1996
3. Journals

EMBRYOLOGY
EMBRYO = embrio
LOGOS = ilmu
Period :
1. Embriogenesis (organogenesis)
2. Fetogenesis

Removal of adherent seminal plasma

proteins
Reorganization of plasma membrane
lipids and proteins
Influx of extracellular
calcium
Increase in cyclic AMP
Decrease in intracellular
pH

UMUR WANITA DAN MASA REPRODUKSI

Tingkat Keguguran (%)

% Fertilitas maksimum

% Fertilitas maksimum
Tingkat keguguran (%)

100

50

80

40

60

30

40

20

20

10

20-24

25-29

30-34

35-39

40-44

Leon Speroff and Frits marc A. Clinical Gynecologic

Endocrinology and Infertility. Ed. VII TH. Lippincott
Williams & Wilkins Philadelphia (2005) p : 1013 - 1056

1. Central & perifer nervous system

2. Epitel of ear, nose, and eyes
3. Epidermis : hair & nail
4. Mamae gland, Hipofise, dan sub
cutis gland
5. Enamel

1. Fibrous tissue, cartilage, bone

2. Striated mucle, smooth muscle
3. Cor, vascular, lymp node & Limfosit
4. Ren, reproductive accesori gland &
duct
6. Lien
7. Cortec of supra renal gland

1.

Epithel digestive

2.

thymus, liver, pankreas

3. Vesica urinary, urethra

4. Epithel cavum thympani
6. Tuba eustachius

15% genetic
factor
10% environmental
factor
25% genetic & environmental
factors
50% unknown

1. Infection
2. Radiation
3. Chemicals, hormone
4. Mothers diseases
5. Environmental agents

Abortion, IUFD

Korioretinitis, ensefalitis,
brain calcification,
hidrosefalus, mikrosefali,
heart malformation, dental
- abnormality
Prevention : Imunisation

- Hepatosplenomegali
-

Mikrosefali

Hidrosefalus

Central paralysis

- Herpes Genital during Partus

- Brain injury, mental retardation
- Prevention: Operasi
Caesar

- Brain development problems

- Heart and urinary problems

Growth development
abnormality
Mikrosefali
Spontan abortion

- Spontan abortion,
IUFD
- Cardivaskuler
abnormality
- Specific face

- Hidrosefalus
- Korioretinitis
- Hepatosplenomegali
- Mental retardation

Steroid Androgen : FEMALE

Masculinisation
Anti Androgen : MALE
Feminization

Mental retardation, low birth

weight

Heavy smoker, hipoxia, low

birth weight

1.

2.

LEVEL OF EMBRYO DEVELOPMENT :

Predifferentiation : all, fatal

Effective differentiation: multiple abnormality

Janin : insensitive

GENOTIP
Genetic stability

3.

TERATOGEN POTENSIAL

ninik_drs@yahoo.com