Evaluation and
Findings
History of alcohol abuse,
increased liverenzyme
levels
Serum vitamin B1 deficiency
History of treatment,
abnormally elevated
serum level (if applicable)
Initial Treatment
Alcohol withdrawal, vitamin B1
supplementation
History of intoxication
Vitamin B1 supplementation
Drug withdrawal, vitamin B1
supplementation
as therapy or as prevention (if
fluorouracil
received)
Immediate cessation of
exposure
Brain MRI
Brain MRI
Brain MRI, cerebrospinal fluid
examination
on direct microscopy
Brain MRI and cerebrospinal
fluid examination
to detect lymphocytic
pleocytosis, serologic
tests for viruses
Brain MRI
Glucocorticoids
Antibiotics
Acyclovir (for varicellazoster
virus)
A.
B.
C.
D.
Cerebellar atrophy
in a patient with
ataxia
telangiectasia.
Periventricular
leukoencephalopath
y (arrows) in a
patient with
cerebrotendinous
xanthomatosis.
cerebellar atrophy
but cervical spinal
cord atrophy
(arrow) in a patient
with Friedreichs
ataxia, 10 years
after the onset of
the disease
T2-weighted linear
hypointensities in
the pons (arrows) in
a patient with
autosomal
recessive spastic
ataxia of
Charlevoix
Saguenay
Jalur Patofisiologi